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《Journal of Apoplexy and Nervous Diseases》 2008-04
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The anti-oxidation and anti-inflammation function of probucol in the patients with carotid atherosclerosis disease

HOU Xiao-qiang,XUE Fei,YUAN Jian-xin,et al.(Department of Neurology,The Affiliated Kailuan Hospital,Northern China Coal Medical College,Tangshan 063000,China)  
Objective To investigate the anti-oxidation and anti-inflammation function of probucol in the patients with carotid atherosclerosis disease by measuring plasma cholesterol,oxidized low density lipoprotein(ox-LDL) and inflammation parameters before and after treatment.Methods 72 patients were divided into treatment group(n=38) and control group(n=34).Patients in the treatment group took probucol besides the routine therapy.The total treatment phase was 12 weeks.Patients in the control group only took the routine drugs and did not take any lipid lowering drugs and other antioxidants.Before and after the treatment,the plasma cholesterol,ox-LDL,high-sensitive C reactive protein(hs-CRP) interleukin-1β(IL-1β) and matrix metalloproteinase-9(MMP-9) were measured.Results After treatment,the levels of ox-LDL,hs-CRP,IL-1β,MMP-9 and cholesterol decreased significantly(P0.05);the differences of ox-LDL,inflammation factors and cholesterol concentration between the two groups were statistically significant(P0.05).Conclusions Probucol could decrease the concentration of plasma cholesterol in the patients with carotid atherosclerosis disease.Probucol could reduce the plasma level of ox-LDL,hs-CRP,IL-1β and MMP-9 significantly,indicating its good effect of anti-inflammation and anti-oxidation.
【CateGory Index】: R543.4
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