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《Journal of Apoplexy and Nervous Diseases》 2012-06
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Effects of β-sodium aescinate on expression of AQP4 in rat models of transient focal ischemia-reperfusion

WANG Hai-he,LU Hong,DING Ji-yan,et al.(Department of Neurology,the First People's Hospital of Xinxiang City,Xinxiang 453000,China)  
Objective To invstigate the expression of AQP4 in rat brain after transient focal cerebral ischemia/reperfusion injury,to observe the therapeutic effects and to explore the mechanisms of β-sodium aescinate.Methods Rat models of transient focal cerebral ischemia/reperfusion was set up by using the method of middle cerebral artery occlusion(MCAO),the brain water content was measured by using dry-wet weight assay,the brain infarct volume was detected by using the technique of TTC,the expressions of AQP4 in rat brain were detected by immunohistochemical SABC method.Results There was a slight expression of AQP4 in sham-operated group with no significant difference compared to contralateral one,AQP4 protein expression in model group and treatment group was significantly increased,the brain water content increased and the brain infarct volume appeared,the expressions of AQP4 in rat brain and brain water content were significantly decreased for the treatment groups by giving β-Sodium Aescinate,and the brain infarct volume was reduced too.The effect of aescin in the middle-high dose group was superior to low-dose group(P0.05).Conclusion The occurrence and development of cerebral edema is closely related to the increase in AQP4 protein expression.In cerebral ischemic territory,β-sodium aescinate has the function of reducing brain edema.
【CateGory Index】: R285.5
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