Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Apoplexy and Nervous Diseases》 2012-06
Add to Favorite Get Latest Update

Effects of β-sodium aescinate on expression of AQP4 in rat models of transient focal ischemia-reperfusion

WANG Hai-he,LU Hong,DING Ji-yan,et al.(Department of Neurology,the First People's Hospital of Xinxiang City,Xinxiang 453000,China)  
Objective To invstigate the expression of AQP4 in rat brain after transient focal cerebral ischemia/reperfusion injury,to observe the therapeutic effects and to explore the mechanisms of β-sodium aescinate.Methods Rat models of transient focal cerebral ischemia/reperfusion was set up by using the method of middle cerebral artery occlusion(MCAO),the brain water content was measured by using dry-wet weight assay,the brain infarct volume was detected by using the technique of TTC,the expressions of AQP4 in rat brain were detected by immunohistochemical SABC method.Results There was a slight expression of AQP4 in sham-operated group with no significant difference compared to contralateral one,AQP4 protein expression in model group and treatment group was significantly increased,the brain water content increased and the brain infarct volume appeared,the expressions of AQP4 in rat brain and brain water content were significantly decreased for the treatment groups by giving β-Sodium Aescinate,and the brain infarct volume was reduced too.The effect of aescin in the middle-high dose group was superior to low-dose group(P0.05).Conclusion The occurrence and development of cerebral edema is closely related to the increase in AQP4 protein expression.In cerebral ischemic territory,β-sodium aescinate has the function of reducing brain edema.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 Sun Jing-jing 1 , Zhang Peng 2 , Zhou Guo-qing 2 1 First Department of Neurology, Tangshan Union Hospital, Tangshan 063000, Hebei Province, China 2 Second Department of Cardiology, Oil Geophysical Prospecting Bureau of Trade Unions Central Hospital, Baoding 072550, Hebei Province, China;Bone marrow mesencyhmal stem cell transplantation combined with edaravone for the treatment of cerebral infarction in rats[J];Chinese Journal of Tissue Engineering Research;2013-19
2 WAHG Yao-hui;LI Guo-hui;Department of Neurology,Affiliated Hospital of Guilin Medical College;;Role of p38 MAPK on cerebral edema and AQP4 expression after cerebral ischemia reperfusion in rats[J];Journal of Apoplexy and Nervous Diseases;2013-08
Chinese Journal Full-text Database 3 Hits
1 LAN Xi-fa, YAO Wen-xiu, GUO Yang (Department of Neurology , The Second Affiliated Hospital, China Medical University,Shenyang110004,China);Expression of aquaporin-4 after cerebral ischemic reperfusion in rats[J];Journal of China Medical University;2004-02
2 HU Bo, SUN Sheng-gang, MEI Yuan-wu, et al The Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan ( 430022 );Protective Effect of Ginkgo biloba Extract on Cerebral Ischemia/reperfusion Injury in Rats[J];Chinese Journal of Integrated Traditional and Western Medicine;2003-06
3 Fan Xuejun, Zi Xiaohong, Guo Ke, et al. Department of Neurology, The Third Hospital Xiangya of Central South University, Changsha 410013;Effect of sodium aescinate on neuronal apoptosis' Gene in brain ischemia and ischemia-reperfusion model of rats[J];Stroke and Nervous Diseases;2005-04
Chinese Journal Full-text Database 10 Hits
1 XIE Ming-jian,XUE Wei-xin//The Traditional Chinese Medicine Hospital of Hezhou City,Hezhou 542800,China;Research situation on lesion of cerebral ischemia-transfusion treated with Traditional Chinese Medicine[J];Acta Medicinae Sinica;2005-05
2 CAO Li-mei,BI Gui-nan※,LUO Chuan-ming△,LI Hao☆,QIU Yan-dong※,LI Bing-ru※,SHI Sheng-liang※. Department of Neurology,Shanghai Yangpu Districs Hospital,(Shanghai 200093),China;Effects of EGb761 on the activities of Caspase-9 and Caspase-3 following ischemic reperfusion injury in rats[J];Guangxi Medical Journal;2006-08
3 ;Progress in Nerves Protective Mechanism of Ginaton[J];Guiding Journal of TCM;2007-07
4 HE Li-xia,FAN Hua(The Second People Hospital of Fushun,Fushun,Liaoning 113001,China);The Effcct of Maitork on the Auditory Recovery of the Patients with Sudden Deaffines[J];Journal of Practical Medical Techniques;2007-12
5 Cheng Hua,Liu Zeng-xu,Xu Nian-xiang,Luo Xiao-feng,Yu Qing,Liu Hui-fang,Liu De-ming Department of Anatomy,Nanchang University,Nanchang 330006,Jiangxi Province,China;Effects of autologous olfactory mucoma combined with beta-aesine sodium on expression of matrix metalloproteinase-2 and matrix metalloproteinase-9 in rats following spinal cord injury[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-45
6 Duan Li,Liu Yongsheng,Zhou Ping (Department of Neurology,the Eighth People' s Hospital of Chongqing,Chongqing,China 400015);Effects of Sodium Aescinate and Naloxone on Cerebral Resuscitation after Successful CPR[J];China Pharmaceuticals;2008-05
7 Xue Qian, Chen Xiaochun The First Affiliated Hospital of Zhangjiakou Medical College, Zhangjiakou, 075000, China;Clinical Study on Treatment of Acute Cerebral Infarction by Combined Application of Ginkgo Biloba Extract[J];Journal of Zhangjiakou Medical Collage;2004-02
8 ZHOU Qing-ping1,LU Jian-feng2,WANG Hui-ping2,XIA Qiang2(1.Department of Geographic and Biologic Sciences,Liupanshui Normal College,Shuicheng 553004,China;2.Department of Physiology,College of Medicine,Zhejiang University,Hangzhou 310058,China);Ginkgo biloba extract protects brain from ischemia/reperfusion injuries[J];Journal of Zhejiang University(Medical Sciences);2010-04
9 CHEN Shu-ping,XU He-yun,WEN Xiao-hong,An Xiao-xia,Xu Ming.First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Protective effects of Ginkgo biloba extract on ischemia-reperfusion lung injury in rabbits[J];Chinese Journal of Transplantation(Electronic Version);2007-01
10 HUANG Xue-shan LIU Xuan CHEN Dao-zhong Department of Cardiovascular Surgery,The Affiliated Union Hospital of Fujian Medical University,Fuzhou(350001);Effect of Ginkgo Biloba Extract Preconditioning on Discordant Cardiac Xenografts[J];Chinese Journal of Integrated Traditional and Western Medicine;2006-S1
Chinese Journal Full-text Database 10 Hits
1 SHAO Bao-ping,YU Hua-sheng,WANG Jian-lin(School of Life Science,Lanzhou University,Lanzhou,Gansu,730000,China);Progress on Aquaglyceroporin 9 in Brain Pathologies[J];Progress in Veterinary Medicine;2012-01
2 WANG Fu-xin1,ZHANG Jie2,WANG Chen1,ZHANG Jun-wu1,HOU Li-chun1,YANG Hui1(1.Department of Neurology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154003,China;2.Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,China);Effects of nimodipine on the expression of AQP4 and MMP-9 in early cerebral hemorrhage rats[J];Heilongjiang Medicine and Pharmacy;2012-04
3 LIU Xin-dong,ZHANG Li-juan,ZHAO Li-jun.Nuke Industry Ministry 416 Hospital,Chengdu,Sichuan 610051,China;An observation on the clinical effect of Edaravone on treatment of massive cerebral infarction[J];Sichuan Medical Journal;2012-03
4 OUYANG Xi-hua,JIA Jun,LIU Zheng-wei.Longgang Central Hospital of Shenzhen,Shenzhen,Guangdong 518116,China;The relationship between the expression of AQP4 and clinical outcomes of head-injured patients[J];Sichuan Medical Journal;2012-04
5 ZHAO Bin,LIU Bin,ZHANG Yuqin Department of Neurology,Affiliated Hospital of Hebei United University,Tangshan 063000,China;Effect of Edaravone on Expression of Caspase-3 and Pdcd-5 Protein after Intracerebral Hemorrhage in Rats[J];Tianjin Medical Journal;2012-05
6 Wu Qiuyi,Xu Shu,Ding Xinsheng(Zhangjiagang First People's Hospital Affiliated to Suzhou University,Zhangjiagang 215600,Jiangsu,China);Neuroprotective effects of edaravone combined with ozagrel sodium on ischemia-reperfusion injury in rats[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2011-10
7 Zhou Guo-qing,Jin Yi,Zhang Peng Oil Geophysical Prospecting Bureau of Trade Unions Central Hospital,Baoding 072550,Hebei Province,China;Treatment of cerebral infarction in rats by transplanting bone marrow mesenchymal stem cells with RhoA gene silencing via the vein[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2010-45
8 Zhang Ting-yong The 163 Hospital of PLA,Changsha 164800,Hunan Province,China;Monosialoganglioside combined with bone marrow mesenchymal stem cells transplantation for the treatment of cerebral infarction in rats[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2011-14
9 YANG Zhen-xing1,LI Zong-zheng2(1.Ningxia Medical University,Yinchuan 750004;2.Department of Neurosurgery, the General Hospital of Ningxia Medical University,Yinchuan 750004);Influence of Small Dose of Dexamethasone on AQP4 in Rats with Brain Trauma[J];Journal of Ningxia Medical University;2012-06
10 ZHAO Xiao-mei,LIU Yong-gang(Department of Neurology,the First Central Hospital of Baoding City,Baoding 071000,Hebei Province,China);Effects of bone marrow mesenchymal stem cells and its supernate on rats with cerebral infarction[J];Journal of Xinxiang Medical College;2012-08
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 CUI Li 1, ZHENG Hui Min 1, NI Can Rong 2, ZHANG Ren Qin 1 (1.Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China; 2.Department of Pathology, Changhai Hospital);Effect of sodium aescinate on neuron apoptosis in focal cerebral ischemia of rats[J];Pharmaceutical Care and Research;2002-01
2 LAN Xu,LIU Xue mei,GE Bao feng,.Institute of Orthopedics,The General Hospital of PLA.Lanzhou 730050;Protective Effect of β-Aescin on Ischemia and Reperfusion Injury of the Limbs[J];THE ORTHOPEDIC JOURNAL OF CHINA;2000-06
3 Xi Gangming, Yu Dongzi, Fan Huayan, et al.Department of Neurology, Taihe Hospital affiliated Yunyang Medical College, Shiyan 442000;Effects of berberine on neuronal apoptosis related gene after global cerebral ischemia in mice[J];Srtoke and Nervous Diseases;2001-06
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved