The protective effects of cerebral carboxyethylgermanium sesquioxide on ischemia-reperfusion injury in rat
Wu Jiliang;Li Lizhong;He Liya;et al.(Department of pharmacoloy, Xianning Medical College, Xianning 437100)
In order to observe the influence of carboxyethylgermanium sesquioxide(CGS) on cerebral ischemia-reperfusion injury in rat,the animal model was established by ligaturing both sides of common carotid artery followed by ing. Levels of malondialehyde(MI)A) and activity of superoxide dismutase(SOD), glutathione peroxidase(GSHPx) and ATPase were determined in the hippocampus of brain that underwent ischemia following reperfusion. The data showed that CGS significantly decreased the level of MDA and had obviously a protective effect on the activity of SOD,GSH-Px, Na+-K+ATPase and Ca24-ATPase. The results suggested that CGS has a protective effect on cerebral ischemia reperfusion injury in rats.