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《Maternal and Child Health Care of China》 2008-13
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The expression of e-cadherin gene relate with malignant transformation in hydatidiform mole

ZHANG Xiu-Fen,CHEN Su-Qin,ZHANG Jie-Ying,et al.Department of Obstetrics and Gynecology,Hebei Medical University,Shijiazhuang 050000,Hebei,China  
Objective:To elucidate the relations between E-cadherin gene expression and malignant transformation in hydatidiform mole.Methods:Immunochemistry was used.A total of 34 cases hydatidiform mole,24 cases non-malignant transforming mole,and 10 cases malignant transforming mole were investigated.Results:The expression of E-cadherin was higher in nonmalignant hydatidiform than that in malignant(P=0.014).The expression in both the two genes had no significant diference in moles that progressed into postmolar tumor compared with those that remitted spontaneously after evacuation.Conclusion:The expression of E-cadherin is correlated with the invasive transformation of trophoblast,and maybe it is the premise of invasiveness of hydatidiform mole.
【Fund】: 河北省科技攻关计划项目(项目编号:02276158)
【CateGory Index】: R737.33
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【Citations】
Chinese Journal Full-text Database 2 Hits
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【Co-references】
Chinese Journal Full-text Database 10 Hits
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