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《Maternal and Child Health Care of China》 2009-26
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Expression of migration inhibitory factor in ovarian carcinoma and the correlation with microvessel density

XIA Xiao-Ai,HE Cheng-Zhang,LV Bei,et al The People's Hospital of Wuxi,Wuxi 214062,JiangSu,China  
Objective:To study the expression of macrophage migration inhibitory factor(MIF) and CD34 in epithelial ovarian carcinoma(EOC),and to investigate the effect of MIF on angiogenesis of carcinoma and determine whether the chemotherapy before operation can inhibit the production of MIF.Methods:Immunohistochemical staining was used for detecting the expression of MIF and CD34 in the tissues of 58 EOC and 19 control.Results:In 58 cases,positive expression rates of MIF was 84.5%,which was much higher than control group(10.5%).The detection of CD34 showed that microvessel density(MVD) in positive specimens of MIF,negative and non-malignant tissues were(34.6±7.1)/HP,(20.1±6.7)/HP and(12.0±7.5) /HP,respectively(P0.000 1 in all).The expression degree of MIF showed a positive correlation with MVD(r=0.67,P0.05).Conclusion:MIF has the function of advancing neovascularization of EOC.Preoperative chemotherapy can't damage significantly the expression of MIF in EOC.
【CateGory Index】: R737.31
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