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《Maternal and Child Health Care of China》 2016-14
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Study on the damage of cadmium on reproductive system of female rats

ZHANG Jun-Feng;MA He-Hong;ZHENG Xin-Ying;The First Department of Obstetrics,Cangzhou Central Hospital;  
Objective To explore the damage of cadmium on reproductive system and the effect on reproductive function of female rats.Methods Twenty female adult SD rats were randomly divided into control group( C group) and cadmium chloride( CdCl_2) group( group Cd).The rats in Cd group were treated by intraperitoneal injection of CdCl_2( 1.0 mg/kg),once a day,five days a week for 6 weeks.The rats in C group were treated by intraperitoneal injection of normal saline of the same volume in the same time points.From the twentieth day,vaginal exfoliated cells smearing method was used every 12 hours to observe and record estrous cycle;after treatment,heart blood samples were obtained in the two groups to detect cadmium and related reproductive hormones levels;uterine and ovarian samples were obtained to detect cadmium levels.Results Compared with C group,estrous cycle and the abnormal rate during estrous cycle increased significantly( P0.05),the levels of cadmium in serum,ovary,and uterus increased significantly( P0.01),serum estradiol and progesterone levels decreased significantly( P 0.01);there was no statistically significant difference in the levels of serum follicule-stimulating hormone( FSH) and luteinizing hormone( LH) between the two groups( P0.05).Conclusion The study further clarifies the reproductive toxicity of cadmium to reproductive system of female rats and the influencing mechanism,uterus and ovary are the target organs of cadmium.
【CateGory Index】: R114
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