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《Maternal and Child Health Care of China》 2019-13
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Application value of thrombelastogram combined with detection of blood coagulation indexes for preeclampsia

DONG Xue-Mei;YE Ping;ZHAO Hui-Min;Clinical Examination Center of Gansu Provincial Maternal and Child Health Care Hospital;  
Objective To analyze the parameters of thrombelastogram( TEG) and blood coagulation in patients with preeclampsia,evaluate the prognostic value of these parameters for prethrombotic state. Methods A total of 296 preeclampsia patients givig birth to their babies in Gansu Provincial Maternal and Child Health Care Hospital from January 2015 to September 2017 were selected and divided into mild preeclampsia group( 140 patients) and severe preeclampsia group( 156 patients) according to obstetric diagnostic criteria; 300 normal late pregnant women during the same period were selected as control group. TEG,conventional blood coagulation detection,antithrombase Ⅲ( AT-III),and D-dimer detection in median cubital vein blood were performed after admission and before delivery. Results There was no statistically significant difference in TEG parameters between mild preeclampsia group and control group( P0. 05). Compared with control group,excluding α angle,R value and K value in severe preeclampsia group increased,MA value shortened significantly,CI value decreased significantly( P0. 05). There was no statistically significant difference in TEG parameters between mild preeclampsia group and severe preeclampsia group( P0. 05). There was statistically significant difference in activated partial thromboplastin time( APTT) between mild preeclampsia group and control group( P0. 05),but there was no statistically significant difference in prothrombin time( PT),fibrinogen( Fg),thrombin time( TT),D-dimer,AT-Ⅲ,and platelet( PLT) among the three groups( P0. 05). There were statistically significant differences in PLT and APTT between severe preeclampsia group and control group( P0. 05),there was statistically significant difference in PLT between severe preeclampsia group and mild preeclampsia group( P 0. 05),but there was no statistically significant difference in other parameters( P0. 05). Conclusion TEG combined with blood coagulation indexes and D-dimer detection can comprehensively reflect blood coagulation state of preeclampsia patients,rapidly and effectively predict blood coagulation state,early intervention may reduce the incidence rates of perinatal bleeding and thrombotic diseases.
【Fund】: 甘肃省卫生行业科研计划项目(GSWSKY-2015-20)
【CateGory Index】: R714.244
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