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The clinicopathologic characters and prognosis of cervical cancer in 831 young women under 35 years old

LIU Lan-fang, SUN Hai-yan (Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou Zhejiang 310022,China)  
Background and purpose:Several prior studies have evaluated that the overall incidence of cervical cancer has decreased in the past 30 years, while it seems that the age of mortality is younger, especially young women under 35 years old. The prognosis of cervical cancer in young women still needs to be determined. The purpose of this study was to determine the main clinicopathologic characteristics of cervical cancer in young women aged under 35 years and the influence of age on prognosis. Methods:A retrospective review was performed for 831 patients under 35 years old , 1 737 cases over 35 years old was used as a control group. Clinical and pathologic variables including clinical stage, pathological type, tumor size, lymph node metastases(LNM),depth of invasion(DI) and lymphovascular space involvement (LVSI)were analyzed using Peason chi-squowe test. The 5-year survival and 2-year recurrence rates were analyzed by Kaplan-Meier method.Results:The younger patients were characterized by a higher rate of early stage with 64% vs 37.8% in control group(P=0.000),non-squamous cell carcinoma were 14.90% in the study group and 6.80% in the control group(P=0.000),bulky lesion were 52.00% vs 30.44%(P=0.000), LNM were 33.46% vs 23.93% (P=0.000),deep stroma invasion(DSI) were 51.88% vs 39.94% (P=0.005),There was no significant difference in LVSI for two groups with 37.03% in the young group and 38.26% in the control group (P=0.663).The clinical stage and tumor size of young patients were related with LNM,DI and LVSI(P0.05),the pathologic type in the study group was only related with LVSI, LVSI in squamous cell carcinoma was 40.40% vs 66.00% in non-squamous cell carcinoma (P=0.002).The 5-year survival rate was 75% and 39.8% in early and advanced stage in young patients, 84.38% and 54.13% in control group respectively(P=0.000).The 2-year recurrence rate for two groups were 31.95% vs 15.97%(P=0.000) in early stage, 45.48% vs 25.99% in advanced stage(P=0.000).Conclusions:The features of cervical cancer in young women under 35 years old have a high rate of early stage ,bulky lesion, non-squamous carcinoma and higher risk factors in postoperative pathology. The prognosis of cervical cancer in young women is poorer than older patients.
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