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《Journal of China Prescription Drug》 2017-02
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Primary studies on synthesis of aspirin-g-chitosan derivatives

LIU Yong-shan;LIN Rong-xi;ZHAO Zhen-wen;People’s Hospital of Nanhai Foshan;Foshan University;Third People’s Hospital of Foshan;  
Objective To study the synthesis method of aspirin-g-chitosan derivatives. Methods Under the catalysis of DCC and DMAP, certain amount of aspirin and chitosan were added into the amount of chloroform, reactiing 6 h at 50℃. The products were separated by column chromatography and preparative TLC. Then, TLC, IR, UV were used to characterize the product. Results After analysis of TLC, IR and UV, the obtained product is a single component, and it can be identified as aspirin-g-chitosan amide derivatives. Conclusion Under the condition of appropriate catalyst, taking aspirin and chitosan as raw materials, aspirin-g-chitosan derivatives can be synthesized preliminary by appropriate separation and purification methods.
【Fund】: 佛山市医学类科技攻关项目(2014AB00258)
【CateGory Index】: R914.5
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