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《Chinese Journal of Ultrasound In Medicine》 2002-11
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Ultrasonographic Detection of Endothelial Function in Chronic Renal Failure (CRF) Patients

Fu Zhao,Zhou Qichang,Fang Ping,et al Ultrasonography Department,2nd xiangya Hospital of Contral South University,Changsha,410011 Hunan  
Objective:To determine whether the vascular endothelial function in chronic renal failure patients is abnormal, we assessed the flow-mediated endothelium-dependent vasodilation (EDVD) in the brachial artery.Methods:The subjects consisted of 20 patients with uremia, 15 patients with azotemia and 15 age?sex-matched healthy controls We measured the diameter and velocity of the brachial arteries at rest, during reactive hyperemia (flow-mediated endothelium-dependent dilatation) and after sublingual glycerytrinitrate (GCN; causing endothelium-independent vasodilation).Results:EDVD in uremia patients was less than that of normal controls(6 7%±1 6% VS 13 1%±2 7%, P 0 05), and either less than that of azotemia patients(6 7%±1 6% VS 8 7%±1 7%%, P 0 05), which obviously decreased when compaired with that of controls(8 7%±1 7%%VS 13 1%±2 7%, P 0 05) After hemodialysis, EDVD was less than that measured before in uremia patients, and had statistic significance(6 7%±1 6% VS 4 8%±1 5%, P 0 05) Endothelium-independent vasodilation had no significance between the groups.Conclusions:Endothelial function is abnormal in patients with chronic renal failure, and accelerates with the development of the disease;and hemodialysis may injure endothelial function.
【CateGory Index】: R445.1
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