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《Chinese Journal of Ultrasound In Medicine》 2005-01
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Diagnostic Value of Endometrial Volume Measurements in Endometrial Carcinoma Using Three-dimensional Transvaginal Ultrasound

Ge Ling,Fu Qingzhao,Liu Shaoping,et al Department of Ultrasound,Qilu Hospital Affiliated to Shandong University,Jinan 250012 China  
Objective To compare the value of endometrial volume measurements with VOCAL(virtual organ computer-aided analysis) software and with endometrial thickness measurement in diagnosing endometrial carcinoma.Methods The study included 49 patients with postmenopausal irregular vaginal bleeding and 20 postmenopausal asymptomatic women.For each patient,2D-TVS and 3D-TVS were performed with the endometrial thickness and volume measurements.All ultrasound data were verified by pathological results or postoperative histopathological findings.Results Of the 69 patients,25 cases were diagnosed as endometrial atrophy,14 cases as hyperplasia,30 cases as endometrial carcinoma.The mean volume of endometrium in women with atrophy,hyperplasia and carcinoma were 1.15±0.62 ml,11.52±4.94 ml,19.54±7.34 ml,respectively.The mean thickness of endometrium in the three groups were 3.30±1.10 mm,13.8±6.00 mm,15.2±5.80 mm,respectively.There was a significant differences in endometrial volume between each pair of study groups(P0.05),but there were not significant difference in endometrial thickness between hyperplastic endometrium and endometrial cancer.In order to evaluate the diagnostic value of endometrial volume and endometrial thickness for endometrial cancer,we set up their ROC curves.The area under the volume curve was 0.92,while that of the endometrial thickness was 0.833.According to ROC analysis,if the cut-off value of endometrial volume ≥13.00 ml was used,the sensitivity,specificity for endometrial cancer were 93.3% and 82.1%,respectively,if the thickness≥5.00 mm was used,the sensitivity,specificity were 90% and 51.3%,respectively.Conclusions Compared with endometrial thickness,endometrial volume measurement is more useful in the diagnosis of the endometrial cancer.
【CateGory Index】: R737.33
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