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Correlation of Contrast-enhanced Ultrasonography with Tumor Angiogenesis in Hepatocellular Carcinoma(part II)

Jiang Honghong,Li Anhua,Zhou Jianhua,et al National Key Laboratory of Huanan Oncology,and Department of Ultrasound, Tumor Hospital,Affiliated to Zhongshan University,Guangzhou 510060 China  
Objective To explore the correlation of contrast-enhanced ultrasonography(CEUS)with tumor angiogenesis in hepatocellular carcinoma(HCC).Methods CEUS was performed before operation in 47 patients with HCC.Time-intensity curves(TIC)in 43 cases with HCC were analyzed.Pathologic grading for HCC was determined according to the scale of Edmonson.Tissue specimens of HCC in 47 cases were stained with CD34 by immunohistochemical method.The perfusion parameters obtained by the TIC were analysed to explore the relationship between the perfusion data and angiogenesis.Results There were significant differences between microvessel density(MVD)and pathologic grading of HCC(P0.05),but not between tumor size and pathologic grading of HCC(P0.05);The characteristics of microvessels were significantly related to pathologic grading in HCC(P0.05);There were statistically positive correlations between peak intensity(PI)and enhancement duration time(EDT)and MVD(r=0.36,P=0.02;r=0.45,P=0.003),respectively.There were no obvious correlation between the perfusion parameters and the patterns of microvessels in 43 HCC(P0.05).Conclusions The perfusion data correlated with tumor angiogenesis in HCC,thus CEUS offers a new way to judge the tumor angiogenesis in vivo.
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