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Establishment of Normal Range and Values of Biochemiccal Data Measurements In SPF Wistar Rat

WU Xiao-yan~1,WANG Dong-ping~1,HE Li~2,SHANG Shi-chen~1,SUN Yan-song~1,LI Gui-jun~1,FAN Xiu~1(1.Laboratory Animal Center,Academy Of Medical Sciences,Beijing 100071,China;2.College Of Life Science,Capital Normal University,Beijing 100073,China)  
Objective To establish normal range and mean values of serum biochemical measurements in SPF Wistar rat used in long-time toxic test.Methods Serum was sampled from SPF Wistar rat on Day 20,30,40,50.Twenty-seven serum biochemical parameters were measured using an automatic biochemical analyzer.Results To establish normal range of twenty-seven serum biochemical parameters on SPF wistar rat,significant differences of biochemical data were found in male and female on SPF Wistar rat in 20、30 days,significant differences of biochemical data were found in male and female on SPF Wistar rat in 40、50 days,there were differences in different days,there were difference in rule.The values of ALT,ALB,CREA,AG,TP,GLB,ALP,TG,MG were increased as rats grow,but the values of PO_4,AST/ALT,BUN,URIC,BUN/CREA,CK,LD,CHOL,CL,OSM were decreased as rats low.No changes were found in the values of AST,CA.Conclusion The biochemical data of 40 days SPF Wistar rat were affected by sex and days.The results could be used as normal biochemical value in SPF Wistar rat.
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