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《Chinese Journal of Comparative Medicine》 2019-08
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Down-regulation of CD4~+ T cells in fetal heart tissue of rats with gestational diabetes mellitus

WAN Xuechao;LU Qiufen;HE Yuling;FANG Yan;Tongren City People's Hospital;  
Objective To investigate the level of CD4~+ T cells and related mechanisms in fetal heart tissue from female rats with gestational diabetes mellitus(GDM). Methods Eighty pregnant female Sprague-Dawley rats were randomly divided into normal control(NC) group and GDM group induced by streptozotocin. CD4~+ cell levels were detected in the fetal heart tissues of different groups. Western blotting was performed to detect the interleukin(IL)-17, IL-4, T-cell immunoglobulin mucin(Tim)-3, and programmed cell death protein(PD)-1 expressions, and real-time PCR was used to detect the expression of miR-233-3 p. Results The expression of CD4~+CD25~+ Treg cells in the GDM group(46.41±10.94%) was significantly higher than in the NC group(21.63±10.94%)(P0.01). Expression levels of IL-17, Tim-3, and PD-1 were also significantly higher in the GDM group than in the NC group, while the expression of IL-4 was significantly lower(P0.05 or P0.01). The relative expression of miR-233-3 p in the GDM group(0.682±0.104) was significantly lower than in the NC group(0.466±0.117)(P0.05). Conclusions Cardiac tissue abnormalities in GDM rats may be associated with the down-regulated expression of CD4~+ T cells, and the underlying mechanism may be associated with the down-regulation of miR-233-3 p expression in the fetal rat heart tissue.
【CateGory Index】: R714.256;R-332
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