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《Chinese Journal of Comparative Medicine》 2019-08
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Research advances in the preparation and application of porcine small intestinal submucosa as a tissue-repair material

SU Xiang;GE Liangpeng;LI Qianyong;Chongqing Academy of Animal Sciences;College of Animal Science,Southwest University;Chongqing Medical Animal Resources Development and Utilization Engineering Technology Research Center;  
Small intestinal submucosa(SIS) treated via decellularization technology is a natural extracellular matrix material. Because of its low immunogenicity and good biocompatibility, decellularized SIS is widely used for tissue regeneration and repair. However, the biological characteristics of SIS must be accurately understood to better transform and apply SIS in regenerative medicine. The function of SIS as a tissue-repair material depends on its composition and mechanical properties, the small molecules that the SIS degrades after being implanted, and the various properties and functions of these degraded molecules. This article reviews the physical and chemical composition, characteristics, processing method and applications of SIS to help understand the structure and function of SIS and promote its transformation and application.
【Fund】: 国家自然基金项目(81671441);; 现代农业产业体系(CARS-36)
【CateGory Index】: R318.08
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