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《China Public Health》 2001-11
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Cell Bioassay for Detecting Paralytic Shellfish Poison

CHEN Jie,et al.China Medical University(Shenyang 110001,China)  
Objective To develop a cell bioassy to detect paralytic shellfish poison.Methods Utilizing the sodium channel blocking character of saxtoxin, the standard curve between paralytic shellfish poison and optical density value was constructed.Results The average optical density value of Ouabain/veratridine control group was 0 385 0.The dosage of saxitoxin had a linear correlation with optical density value and the regression equation was y=0 399 6+0 503x ( r =0 988 0, P 0 02).Conclusion Within 0-0 6ng of saxitoxin,there was a dose-response relationship between the dosage of saxoxin and optical density value.The detecting method of the cell bioassay could be used to detect the toxins of paralytic shellfish poison.
【Fund】: 辽宁省科学技术厅资助课题 (课题号 :992 2 80 0 1 )
【CateGory Index】: R99
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