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《Chinese Journal of Public Health》 2009-03
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Inhibitive effect of spirulinahinase extraction on thrombus formation in rats

LI Xiao-hua,CHEN Gao-si,PANG Hui,et al.Department of Physiology,Guangxi Medical University(Nanning 530021,China)  
Objective To study the efect of spirulinakinase(SPK) extraction on thrombus formation and to explore its anti-thrombus formation mechanisms.Methods The coagulation time(CT)were compared between SPK group and control group with capillary vessel and sheet glass after SPK was injected intravenously into the rats.After adding certain concentration of SPK extraction solution to the plasma in vitro and injecting SPK extraction solution into femoral vein,the activated partial thromboplastin time(APTT),prothrombin time(PT) and thrombin time(TT) were tested.Results Due to the use of SPK extraction,the CT of the rats was significantly prolonged;the PT,the APTT and the TT were elongated.Conclusion The SPK extraction shows an obvious anti-coagulation effect in rats.
【Fund】: 广西科学研究与技术开发计划项目(桂科攻0719006-2-27)
【CateGory Index】: R285.5
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