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《Chinese Journal of Public Health》 2009-06
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Influence of baicalin on superoxide dismutase and malondialdehyde in rats with Pneumocystis carinii pneumonia

ZHOU Ling,ZHOU Bi-ying.Department of Traditional Chinese Medicine,the Affiliated Hospital of Zunyi Medical College(Zunyi 563003,China)  
Objective To study the influence of baicalin(Bai) on superoxide dismutase(SOD) and malondialdehyde(MDA) on Pneumocystis carinii pneumonia(PCP) model rats.Methods Sprague-Dawley(SD) rats were subcutaneously injected with dexamethasone sodium phosphate.The treatment group was treated by baicalin before and after the PCP model established.The pathological change in lung tissue and the level of SOD and MDA in sera and lung homogenate were observed.Results Compared with model group,Bai lightened the inflammation of lung tissue,increased the activity of SOD and decreased the content of MDA in the sera and lung homogenate with significant difference.Conclusion Bai has antioxidation effect in the treatment of PCP in rats and may decrease the content of MDA and increase the activity of SOD and lighten the inflammation reaction in PCP rats.
【Fund】: 贵州省卫生厅基金(D-297);; 遵义医学院基金(F-243)
【CateGory Index】: R285.5
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