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《Chinese Journal of Public Health》 2012-09
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Impact of low dose cadmium on development of immature female ovary

LIU Jin*,WU Ting-ting,SHEN Xiao-hua,et al(*Department of Occupational and Environmental Health,School of Public Health,Fujian Medical University,Fuzhou,Fujian Province 350004,China)  
Objective To study the effects of cadmium exposure on expression of hormone,including estradiol(E2) and progesterone(P4) and follicle development and to elucidate whether cadmium has toxicity in immature ovary.Methods Totally 48 Wistar rats were exposed to cadmium by intraperitoneal injected at the dose of 0,0.1,0.3 and 0.9 mg Cd2+/kg body weight,once a day for 19 days.After the exposure,the rats' ovaries were prepared to detect expression of follicles.The sera of the rats were sampled to determine E2 and P4 levels.Results E2 levels in each dosage groups(6.04±0.28,6.10±0.1,and 5.96±0.18 pg/mL) were statistically significantly lower than that of the control group(6.62±0.24 pg/mL,P0.05).The follicle expression in 0.9 mg Cd2+/kg group was different from that of the control group(P0.05).Conclusion Cadmium has obvious toxicity to immature female ovary development.
【Fund】: 高等学校博士学科点专项科研基金(20113518110004)
【CateGory Index】: R114
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