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《Chinese Journal of Hypertension》 2003-04
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Efficacy and Safety of Torasemide in Patients with Mild to Moderate Essential Hypertension

SU Qi 1, LI Yishi 1, CHEN Junzhu 2, et al (1 Department of Clinical Pharmacology, Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC, Beijing 100037 China 2 Department of Cardiology, First hospital of ZheJiang University, HangZhou ZheJiang 310003 China)  
Objective To evaluate the antihypertensive effect and safety of torasemide in Chinese patients with mild to moderate essential hypertension Methods After 1~2 weeks wash out, patients with mild to moderate essential hypertension(seated DBP 95~115 mmHg), were randomly assigned to received torasemide 5 mg or indapamide 2 5 mg once a day for 4 weeks, followed by a double dose for another 4 weeks in patients whose seated DBP were still ≥90 mmHg Blood pressure, heart rate, symptoms and signs were examined at the end of wash out and 2, 4, 6, 8 weeks Laboratory examinations were performed at baseline, 2 weeks and the end of the trial Results 130 essential hypertensive patients were recruited and randomized to receive either torasemide group ( n =64) or indapamide group ( n =66) 118 patients completed the trial, 56 patients in torasemide group(30 finished at the end of 4 weeks and 26 finished at the end of 8 weeks) and 62 in indapamide group(41 finished at the end of 4 weeks and 21 finished at the end of 8 weeks) At the end of 4 weeks, the effective rate was 67 86% in torasemide group and 72 58% in indapamide group At the end of 8 weeks, the effective rate in those whose dosage was doubled was 34 62% in torasemide group and 61 90% in indapamide group No statistical difference was found ( P =0 67) The decrease of seated DBP was of no differece between the two groups at the end of 2, 4, 6, 8 weeks The values of serum potassium, sodium, chloride were lower in indapamide group than those in torasemide group at 2 weeks and the end of the trial ( P 0 01 or P 0 05) Conclusion Torasemide 5 mg/d~10 mg/d is as effective as indapamide 2 5 mg/d~5 mg/d in patients with mild to moderate essential hypertension The impact of torasemide to serum electrolyte is much less than that of indapamide
【Fund】: 国家“十五”重大科技专项课题 ( 2 0 0 2AA2Z34 11)
【CateGory Index】: R544.1
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