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Changes in Plasmic and Lymphocytic AngiotensinⅡ, Endothelin and Nitric Oxide in Patients with Essential Hypertension

Yu Jing,Wang Yongming, Xin Nan(Department of Cardiovascular Medicine, Second Affiliated Hospital, Lanzhou Medical College, Lanzhou)  
Aim\ To examine the changes and the relationships of plasma and lymphocytic angiotensinⅡ(AngⅡ),endothelin(ET) and nitric oxide(NO) in essential hypertensive(EH) patients.\ Methods\ 39 EH patients and 41 nomotensive controls(NC) were studied. AngⅡ,ET were detected by radioimmunoassay and NO was measured by high performance liquid chromatograghy.\ Results\ The levels of plasma and lymphocyte AngⅡ, ET in EH group were higher than those in NC group(P005 or P001).\ The part alternate in stage Ⅱ EH were more obvious then those in stage Ⅰ.\ Multiple progressive regression analysis indicated that MAP has a positively correlated with AngⅡand ET, but negative correlated with NO(plasma: r=067;lymphocytes: r=081 P001).\ In EH groups, NO has negative correlation with AngⅡand ET(plasma: r=-0651; lymphocytes: r=-0725, P001).\ ConclusionLymphocytes could be used as an indirect method to estimate the endocrine function of endothelium cells. It is more sensitive and has a better correlation with MAP than those in plasma. The imbalance of these biological substances may contributes to hypertensive pathogenesis.
【CateGory Index】: R544.1
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