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Study of the mechanism on immunotoxicity of cadmium

ZHANG Xian;Xian Bin;WEI Xue-tao;LEI Zhi-ming;LIU Zhan;ZHOU Hong (Department of Toxicology, Beijing Medical University, Beijing, 100083, China). China Environmental Science. 1999,19(6): 530--535  
In order to study the mechanism on the immunotoxicity of cadmium initially from the view of the regulationand control of the function of immunocyte, mice were treated with 0.3-2.4mg/kg/d CdCl2 by gavage for 14 days. After thetreatment of face the changes of weight of immune organs, immune function, the intercellular concentration of Ca2+ inlymphocyte, the amount of calmodulin in lymphocyte, the NO, O2-,H2O2 in macrophage were tested. The results didn'tshow any change on the weight of immune organs after 0.3-2.4mg/kg/d CdCl2 treatment; but the total number of cells inperitoneal lavage from the face treated with 0.3mg/kg/d CdCl2 showed decrease. There appeared inhibition in the function of humoral immunity and phagocytic function of macrophage, the increase on the concentration of [Ca2+], when treated with 0.3mg/kg/d CdCl2. The production of NO, O-2 in macrophage also decreased at this dosage. In vitro study,50umol/L CdCl2 could induce the inhibition of lymphocyte proliferation, the decrease of IL-2, the increase of [Ca2+]concentration and the content of CaM also had the tendency to decrease. So we thought that the immunotoxicity of cadmium might have close relation with the imbalance of Ca2+ stability in lymphocyte induced by cadrium.
【Fund】: 卫生部基金!94-1-268
【CateGory Index】: R994.6
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