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《Chinese Journal of Respiratory and Critical Care Medicine》 2007-04
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Therapeutic effects of quercetin against paraquat-induced acute lung injury in rats

XIAO Xiao-hui,FU Ming-sheng,WAN Yi-xin.Department of Respiratory Disease,Second Hospital,Lanzhou University.Lanzhou,Gansu,730030,China  
Objective To study the therapeutic effects of quercetin against paraquat-induced acute lung injury.Methods Forty-five male SD rats were randomly divided into three groups,ie.a control group(n=5),a paraquat group(n=20),and a quercetin group(n=20).The rats in the paraquat group and quercetin group were all injected intraperitoneally with paraquat(50 mg/kg) to induce lung injury,then the quercetin group was injected quercetin(100 mg/kg) 3 h later.Five rats in each group were sacrificed at 8,24,48,72 h respectively.The levels of malondialdehyde(MDA),superoxide dismutade(SOD) and glutathione peroxidase(GSH-Px) both in plasma and bronchoalveolar lavage fluid(BALF) were detected.Expression of NF-κB p65 in lung was measured by immunohistochemistry staining,and lung wet/dry weight ratio(W/D) were recorded.Results Comparing the paraquat group with the control group,MDA level increased significantly both in plasma and BALF,SOD activitie decreased both in plasma and BALF but increased significantly in BALF 48 h later,and GSH-Px increased siganificently in plasma 48 h later and decreased in BALF.After the quercetin treatment,MDA decreased,SOD and GSH-Px activities increased significantly both in plasma and BALF.The congestion and hemorrhage of alveoli got improvement.The expression of nuclear factor kappa B(NF-κB) p65 in lungs and W/D were decreased as well in the quercetin group(P0.05).Conclusion Quercetin has therapeutic effects on paraquat-induced acute lung injury in rats.
【CateGory Index】: R285.5
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