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《Chinese Journal of Respiratory and Critical Care Medicine》 2013-05
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The Expression and Implication of Serum Adiponectin in Patients with Asthma

DING Nian-chang;DENG Xing-qi;ZHOU Ling;GU Wei;LI Yan-yan;Department of Emergency Medicine,Central Hospital of Minhang District of Shanghai;  
Objective To measure the serum level of adiponectin and explore its clinical implication in patients with asthma in acute exacerbation and remission phase.Methods 97 patients with asthma were recruited,including 50 patients with asthma in acute exacerbation and 47 patients in remission phase from October 2010 to September 2011.27 healthy nonsmoking volunteers of normal weight(BMI range of 18.5-24.9 kg / m2) were included as control.The concentrations of adiponectin and tumor necrosis factor alpha(TNF-α) in serum were measured by enzyme-linked immunosorbent assay(ELISA).The lung function was tested in all subjects.The correlations between adiponectin,TNF-α and lung function were investigated.The data was analyzed using SPSS 19.0 software.Variables were compared with one-way ANOVA.The correlations between variables were analyzed using Peason 's correlation coefficient or Spearman correlation coefficient.Results Serum adiponectin level was significantly lower in the patients with asthma in acute exacerbation [(246 ± 1.21) ng / mL]than that in the healthy subjects [(9.64 ± 4.88) ng / mL] and the patients in remission phase [(3.79 ± 0.96) ng / mL](P 0.01),while serum adiponectin level was also significantly lower in the patients in asthma remission phase than that in the healthy subjects(P 0.01).The serum adiponectin level in the patients with asthma in acute exacerbation or in asthma remission phase was negatively correlated with the serum TNF-α level(P 0.01),and was positively correlated with FEV 1 / predicted value(P 0.01).Conclusions The serum adiponectin is reduced in asthma patients and may play a protective role in asthma.
【Fund】: 上海市医学重点专科建设项目(编号:ZK2012A23)
【CateGory Index】: R562.25
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Chinese Journal Full-text Database 2 Hits
1 GUO Mao-qing,ZHU Shu-yang.Department of Respiratory Medcine,Affliated Hospital of Xuzhou Medical College.Xuzhou,Jiangsu,221002,China;Effects of Adiponectin on Proliferation of Airway Smooth Muscle Cells and Activation of Adenosine Monophosphate-Activated Protein Kinase[J];Chinese Journal of Respiratory and Critical Care Medicine;2010-03
2 XIE Juan,DENG Xing-qi,LONG Wei,SHI Jin-dong,HE Ming-zhen.Emergency Department,Fifth People's Hospital of Shanghai,Fudan University.Shanghai,200240,China;Plasma Level of Adiponectin and Its Relationship with Interleukin-17 in Patients with COPD[J];Chinese Journal of Respiratory and Critical Care Medicine;2011-01
Chinese Journal Full-text Database 1 Hits
1 ZHANG Hong LAN Yingxia YANG Zhiwei ZHANG Wenwu Emergency Department,Baoan District People's Hospital of Shenzhen City in Guangdong Province,Shenzhen 518101,China;Effect study on change and significance of leptin,adiponectin,C-reactive protein in patients with acute exacerbation of chronic obstructive pulmonary disease[J];China Modern Medicine;2012-28
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