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《Chinese Journal of Blood Purification》 2004-02
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The influence of angiotensin II on human renal interstitial fibroblast proliferation

WANG Jianqin, WEI Tao, YU Zhongyuan. Renal Division, Beijing University People's Hospital, Beijing 100044, China  
Objective Observing the influence of angiotensin II on human renal interstitial fibroblast(HRIF) proliferation. Investigating the role of angiotensin II in the progress of kidney prolifrative diseases at the cell level.Methods Separated and cultured renal interstitial fibroblast were identified. To observe the effect of angiotensin II on the cell cycle and DNA synthesis of HRIF and the inhibitive effect of Losartan, the 3 H-TDR incorporation, flowcytometry and immunohistochemical technique were applied. Result ① Angiotensin II (10 -10 M~10 -6 M) has elevated the incorporation rate of HRIF 3 H-TDR and has showed dose-dependence in day 1 and day 3 (γ 1=0.709 P0.010;γ 3=0.806,P0.010). ②Angiotensin II (10 -8 M~10 -5 M) has markly promoted the transformaion of HRIF from G1 stage to S stage (P0.010). Conclusion. AgII can induce the proliferation of HRIF directly,
【Fund】: 甘肃省科学技术攻关项目 编号:GK972 - 2 - 87A
【CateGory Index】: R334
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