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《Chinese Journal of Blood Purification》 2005-07
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The effect of all-trans-retinoic acid on renal interstitial fibrosis after unilateral ureteral obstruction in rats

ZHU Dan, GUI Baosong, WEI Xiaohong, et al. Department ofNephrology, Second Hospital of Xi'an Jiaotong University, Xi'an 710004, China  
Objective To study the effect of all-transretinoic acid(at-RA) on theprocess of renal interstitial fibrosis following unilateral ureteral obstruction (UUO) inrats. Methods Fouty SD rats were randomly assigned into 5 groups :Two atRA treatment groups(10mg and 20mg·kg-1·d-1 respectively), benazepril treatment group(10mg·kg-1·d-1),UUOcontrol group and normal control group. All of rats were killed 14 days after surgery.Immunohistochemistry was performed on renal tissue to detect smooth muscle actin(α-SMA)which was a cytoskeletal marker of myofibroblast (MyoF) and collagen Ⅲ(col Ⅲ). Histologi-cal studies were also done by he and MASSON stainting. Results Fourteen days after surgery,interstitial myof infiltration and interstitial col Ⅲ deposition were all significantlyreduced by at-RA treatment. At-RA treatment also improved the histological changes of UUOrats. Conclusion Reduction of interstitial MyoF infiltration may be an important event bywhich at-RA prevents renal injury caused by UUO.
【Fund】: 陕西省西安市科技局社会发展项目基金资助项目(GG0414)
【CateGory Index】: R96
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