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Studies on the Cellular Immune Responses of Chickens to Eimeria Maxima Infection

Zha Hongbo et al (College of Veterinary Medicine,China Agricultural University,Beijing 100094)  
The cellular immune responses of chickens to Eimeria maxima reinfection were examined by treating immune chickens with dexamethasone(DEX) and conducting whole blood lymphocyte proliferation assays(LPA)using specific antigens.After challenged with E.maxima,the immunized chickens treated with DEX shed some oocysts while other immunized chickens not treated with DEX shed no oocysts.The results showed that DEX impaired the complete immunity of the immunized chickens to E.maxima reinfection,which suggested that T lymphocytes bearing CD8 antigen,gamma-interferon(IFN-γ)and interleukin-2(IL-2)etc.might play a role in the host defense against E.maxima reinfection.The resulte of the LPA using E.maxima oocyst antigens as stimulants revealed that the stimulation indexes(SI)were associated with the protective immunity of chickens to E.maxima reinfection.Therefore,the LPA could be used to assess in vitro the protective immunity of chickens to E.maxima reinfection.
【CateGory Index】: S852.4,S831.1
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