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A clinical study on human cytomegalovirus infection and nonspecific low back pain

LI Hong,WU Jianxian,HONG Yongfeng,et al. Dept.of Rehabilitation Medicine,Affiliated Hospital of Anhui Medical University,Hefei,230022  
Objective:To explore the relationship of human cytomegalovirus(HCMV) and nonspecific low back pain(NLBP),the correlation of HCMV active infection with clinical symptoms of NLBP and endothelin(ET).Method:Blood and urine samples were collected from 50 patients with NLBP and 36 controls.HCMV-DNA was detected by PCR;inclusion bodies were detected by HE dyeing;HCMV-IgM and IgG were measured by ELISA and ET were examined by radioimmunology assay.VAS and OSW questionnaire evaluation were used to assess clinical symptoms.Result:①NLBP patients had higher positive rates in HCMV antibody and inclusion bodies(P0.05).②In NLBP group,pain duration,pain severity and endothelin level were statistically different in HCMV-IgM antibody positive and negative cases.The differences of t value were-4.74(P0.01)?3.67(P0.01)?4.32(P0.01) respectively.Conclusion:Pain symptoms in NLBP may be related to the active infection of HCMV.After active infection of HCMV,in adult NLBP patients,there were nontypical HCMV inclusion bodies in HE dyeing uropsammus smears under light microscope.
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