Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Rehabilitation Medicine》 2009-11
Add to Favorite Get Latest Update

Effect of acupuncture on modulation of extracellular signal regulated kinase 1/2 and P38 mitogen-activated protein kinase signal transduction pathways in subcutaneous fascia and spinal medulla of rats

JIANG Xuemei, YUAN Lin, ZHANG Xuequan, et al. School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515  
Objective: To observe the effect of acupuncture on the expressions of extracellular signal regulated kinase 1/2(ERK 1/2) and P38 mitogen-activated protein kinase(P38 MAPK) in subcutaneous fascia and dorsal horn of spinal cord of SD rats and the morphologic changes of fascia connective tissue. Method: Twenty SD rats were randomly divided into 4 groups, 5 rats in each group. Rats of acupuncture acupoint group and acupuncture non-acupoint group received hand acupuncture with twist manipulation. Rats of stretch stimulation group received acupuncture with stretch stimulation. The morphologic changes of subcutaneous fascia were observed by phase - contrast microscope. Result: Morphologic changes: fibers of subcutaneous fascia were stretched centripetally to the center of tension, the mean density of cells increased in unit area the configuration of cytoplasm and nucleus were reconstructed as long spindles with unclear boundaries under tension. Changes of signal transduction protein: the expressions of ERK1/2 and P38 MAPK increased especially in acupuncture non-acupoint group; and the location of ERK1/2 and P38 MAPK at neurocyte of spinal cord transferred from cytoplasm to nucleus after acupuncture. The expression of ERK1/2 in neurocyte didn′t enhance, while the expression of P38 MAPK enhanced after acupuncture. Conclusion: Acupuncture could up-regulate the expressions of ERK1/2 and P38 MAPK in local subcutaneous fascia. But the expressions of ERK1/2 and P38 MAPK in spinal cord were not completely coincidence with the expressions in fascia. Acupunture can regulate the nearoactivity and maybe promote the cell differentiation and proliferation of local fascia, and it′s mechanism maybe due to the modulation of ERK1/2 and P38 MAPK signal transduction pathways by destructive factors produced by mechanical stimulation of acupuncture.
【Fund】: 国家重点基础研究计划(973计划)项目(2007CB512705)
【CateGory Index】: R245.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 Feng Ling,Huang Fukai,Zhao Xueping ( China Tibetology Research Center,Beijing Tibetan Medicine Hospital,Beijing,Post code: 100029);Research on Fascia Theory and Surgical Knotty Disease[J];World Chinese Medicine;2013-01
2 SHEN Tian1,LI Zhong-ren2(Nanjing University of CM 1.International Education College,2.The Second Clinical Medical College,Nanjing 210046,Jiangsu Province,China);Acupuncture-moxibustion and mitogen-activated protein kinase signal transduction pathways[J];Chinese Acupuncture & Moxibustion;2012-03
3 LIN Ying,JI Feng1,HUANG Gui-rong1,LI Pei(College of Overseas Education,Fujian University of Chinese Medicine,Fuzhou 350003,China;1College of Acu-moxibustion,Fujian University of Chinese Medicine,Fuzhou350122);Our Considerations about Non-acupoint Selection for Experimental Studies in Rats[J];Acupuncture Research;2013-04
【Citations】
Chinese Journal Full-text Database 7 Hits
1 LI Wei-zhong1, DING Yan-qing2, LI Zu-guo2, ZHANG Jin-hua2 1Department of Stomatology, Nanfang Hospital, 2Department of Pathology, Southern Medical University, Guangzhou 510515, China;Expression of COX-2 and VEGF-C in squamous cell carcinoma of the tongue and its correlation to lymph node metastasis[J];Journal of Southern Medical University;2008-02
2 YUAN Lin1, WANG Jun1, WANG Chun-lei1, SHEN Bao-lin1, DAI Jing-xing1, HUANG Yong21. Teaching and Research Section of Anthropotomy, Southern Medical University, Guangzhou 510515,China2. Teaching and Research Section of Acupuncture and Moxibustion, School of Chinese Medicine,Southern Medical University, Guangzhou 510515, China;Fasciology: A New Theory on the Human Self-supervision and Control System[J];Science & Technology Review;2006-06
3 Wei Gong,Sheng Xu Wang Wei Gong,Sheng Xu Wang,Department of Acupuncture,Faulty of Traditional Chinese Medicine,First Military Medical University,Guangzhou 510515,Guangdong Province,China;Variation and effect of phospho-p38 mitogen-activated protein kinase in reliving pain by electro-acupuncture at jianji acupoint in adjuvant-induced arthritis rats[J];Chinese Journal of Clinical Rehabilitation;2004-08
4 Yuan Lin, Jiao Peifeng, Tang Lei, Huang Wenhua First Military Medical University, Guangzhou 510515;Anatomical Basic of Traditional Chinese Medical Channels[J];China Basic Science;2005-03
5 JIANG Zhongli, CHEN Jiawei, ZHU Hongjun, et al.//Chinese Journal of Rehabilitation Medicine, 2003, 18(2):69-71;Effects of exercise and insulin on c-Jun NH_2-terminal kinase activity and p38 phosphorylation in skeletal muscle of rats with hyperglycemia[J];Chinese Journal of Rehabilitation Medicine;2003-02
6 HU Ruiping, WU Yi,HU Yongshan Author′s address Dept. of Rehabilitation Medicine,Huashan Hospital,Shanghai,200040;Effects of exercise on the protein expression and activity of signaling proteins of insulin in the skeletal muscle of rats[J];Chinese Journal of Rehabilitation Medicine;2005-06
7 ZHANG Yang,YUE Shouwei,WAN Zibing,et al. Author′s address Dept. of Rehabilitation Medicine,Qilu Hospital,Shandong University,Ji′nan,250012;Research of electrophysiological properties of mechanosensitive channels in cultured dorsal root ganglion neurons of neonatal rats[J];Chinese Journal of Rehabilitation Medicine;2006-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 PAN Zhan-heng,LUO Qing-yuan,HU Yong-xiang,FENG Wo-jun,DAI Jing-xing,YUAN Lin(Department of Human Anatomy,Southern Medical University,Guangzhou Guangdong 510515,China);New Yijin Therapy for Thoracic Facet Joint Disorders:A Report of 40 Cases[J];Journal of Anhui Traditional Chinese Medical College;2011-04
2 Xu Xiangdang1,Lou Xinfa1,Jiang Songhe2 1.Wenzhou Medical College(325000);2.The Second Affiliated Hospital of Wenzhou Medical College;An Anatomical Study of the Chengqi (ST1)[J];Journal of Zhejiang University of Traditional Chinese Medicine;2008-02
3 YANG Weisheng Department of Physics, Peking University, Beijing 100871; Institute of Physics, Chinese Academy of Sciences, Beijing 100080;;Investigation of the Lower Resistance Meridian Ⅳ.Speculation on the Physiological Functions of Acupuncture Meridians[J];Acta Scientiarum Naturalium Universitatis Pekinensis;2008-02
4 BAI Zhen-min1,WANG An-li1,LI Sheng-zhi2(1.Sport Rehabilitation Department,Beijing Sport University, Beijing 100084,China;2.College of Preclinical Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang China);Mechanism study on Exercise's effection on mRNA expression of GLUT4 and Akt2 in muscle cells of insulin resistance rats[J];Journal of Beijing Sport University;2010-06
5 WU Sui-sheng,WANG Zan,PANG Li,WANG Lin-quan (Department of Cadre Ward,First Hospital,Jilin University,Changchun,130021,China);Effect of candesartan on ERK1/2 protein expression in myocardium of epilepsy rats induced by kainic acid and its mechanism[J];Journal of Jilin University(Medicine Edition);2008-03
6 LIU Qing-meiCapital Institute of Physical Education,Beijing 100088,China.;Effects of Sports on p38MAPK[J];Journal of Capital Institute of Physical Education;2007-04
7 CHEN Bo1,XIE Xi-mei1,JIA Ying2,LV Ming-zhuang2(1Guiyang College of TCM,Guiyang 550002,China;2Guiyang Medical College,Guiyang 550004,China);Study on synthesis and liberation of NO and IL-1β from fascia tissue cells of rat under pressure stimulation in vitro[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-07
8 ZHAO Li-yun,ZHANG Ming,ZHAO Fu-jian,BIAN Xuan,SUN Jie,ZHENG Zhi-zhong,LI Yuan,WU Yu-ze,GUO Shun-gen(Beijing University of Chinese Medicine,Beijing 100029,China);Progress of fascia and meridian[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-08
9 LIU Fang 1, CHEN Er Yu 1, DANG Rui Shan 1, CHENG Huan Sheng 2 (1.Department of Anatomy, Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China; 2. Institute of Modern Nuclear Physics, Fudan University) [;Distribution of vessel and calcium on tibial margin of leg interosseous membrane[J];Academic Journal of Second Military Medical University;2000-08
10 Qian Rong1,Tan Yan2,Wang Zongbao2,Ye Hong1 (1Department of Nursing,Bengbu Medical College,Bengbu,Anhui Province,233000;2Shanghai University of Sport,Shanghai,200438,China);Expression of insulin receptor mRNA in skeletal muscle and oxidative stress change in diabetic rats at different intensity training[J];Acta Academiae Medicinae Militaris Tertiae;2010-09
China Proceedings of conference Full-text Database 10 Hits
1 ;Study on surface infrared radiation spectrum of Danzhong(RN 17) in the patient with different syndromes of hyperplasia of mammary glands[A];[C];2011
2 Chen Bo~1 Luo Yongfen~2 Cui Jin~1 Feng Lingmei~1 Yong Xiaofang~1 Feng Lin~1 (1.Guiyang College of TCM,Guiyang 550002,China; 2.Chengdu University of TCM);A comparative study on the release of PGE_2 and IL-6 by taking static pressure on fibroblast cells gained from the rat“Zusanli” and its adjacent areas[A];[C];2007
3 JIANG Xiao-ping (Graduate School of Beijing Sport University,Beijing 100084);The relationship between the transmembrance skeleton protein—Integrin and signal transduction and the research advancement on exercise and training[A];[C];2007
4 GUO Chang-qing RUI Na LIU Yan-gang LIU Yun-xia~2 SHA Yan~3 MA Guang-hao~4 (1.College of Acu-puncture & Moxibustion,Beijing University of TCM,Beijing 100029,China. 2.Dongzhimen Hospital,Beijing U-niversity of TCM; 3.China-Japan Friendship Hospital; 4.General Hospital of Navy);Multi-central randomized controlled observation on clinical therapeutic effect of the newBian-stonetherapy on scapulohumeral periarthritis[A];[C];2008
5 YU Hua~1,FAN Lin-lin~1,PEN Jie~1,WU Bing~1,ZHENG Min-qin~2,HUANG Di-jun~3 (1.JIUZHENTANG,The institute of Sichuan province for the weight reduction and health protection,Chengdu 610031;2.Chengdu General Hopital;3.Chengdu Vniversity of cheinese Medicine);Study on Cutaneous Region Needling Technigue for Treatment of Simple Obesity[A];[C];2009
6 WANG Chun-leil,2,YUAN Lin2,WU Jin-peng2 (1 China Academy of Chinese Medical Sciences,Bei Jing 100007;2 Southern Medical University Guang Zhou);Application of 16-row spiral CT and three-dimensional reconstruction techniques on the study of anatomic characteristics of acupuncture points' distribution on the human body[A];[C];2009
7 YUAN Lin1,Bai Yu1,HUANG Yong2,WANG Chun-lei2,WANG Jun1,Wu Jin-peng1,DAI Jing-xing1,YAO Da-wei3 (1.Department of Anatomy,2.Department of Traditional Chinese Medicine,Southern Medical University, Guangzhou 510515,China;3.Department of Anatomy,Chinese University of Hong Kong,Hong Kong);Anatomical Discovery of Meridians and Collaterals Lead to The New Theory of Fasciaology[A];[C];2009
8 Wang Chun-lei (Institute of Basic Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing, China);A CT study on the relationship between Acupuncture points and fascia converging areas and its application on JingJin associated therapeutic methods[A];[C];2010
9 YUAN Lin1,BAI Yu1,HUANG Yong2,WU Jin-peng1,WANG Chun-lei1,WANG Jun1,DAI Jing-xing1,SHA Ou1,YAO Da-wei3.1.Department of Anatomy,Southern Medical University,Guangzhou 510515,China;2.Department of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;3.Department of Anatomy,Chinese University of Hong Kong,Hong Kong 999077,China;Anatomical Discovery of Meridians and Collaterals and the New Theory of Fasciaology[A];[C];2010
10 Wang Cunxin(The Third Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China);The Applications of Microdialysis in TCM,Pharmacology Experiments and Clinical Medicine[A];[C];2008
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 SHEN Guo ming, XU Ying,L Lei,WANG Wang jiu, XU Guan sun (Departerment of Integrated Traditional Chinese and Western Medicine, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Effect of Electro-acupuncture on the Immunoreactivity of Vasoactive Intestinal Peptide in Gastric Mucosal Injury Rats[J];Journal of Anhui Traditional Chinese Medical College;2004-03
2 WANG Hang1,HUANG Hao2,CAI Ke-yin1(1.Second Department of Geratology,Wuhan General Hospital of Guangzhou Command,Chinese PLA,Hubei Wuhan 430070,China;2.Division of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science & Technology.Hubei Wuhan 430022,China);Effects of Electroacupuncture at Jiaji Acupoints on Pain Threshold in Arthritis Rats by Phosphorylation p38 MAPK Signal Pathway[J];Journal of Anhui Traditional Chinese Medical College;2010-05
3 HE Zong-bao1,HU Ling2,SHEN Xiao-ming2,ZHU Qi-chao2(1.Armed Police Corps Hospital in Anhui Province,Anhui Hefei 230041,China;2.Clinical College of Acupuncture,Moxibustion,Orthopedics and Traumatology,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Regulatory Effects of Electrocupuncture of Different Acupoint Combination on Functions of Reproduction-endocrine-immune Network in Perimenopausal Rats[J];Journal of Anhui Traditional Chinese Medical College;2010-06
4 GAO Fang1,WU Sheng-bing2,CAO Jian3,WU Jie1,ZHOU Mei-qi1(1.Clinical School of Traditional Chinese Medicine,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China;2.Center for Scientific Research and Experiment,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China;3.Department of Science and Technology,Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Effects of Electroacupuncture along Heart Channel and Pericardium Channel on Amplitudes of J Point and T Wave of Electrocardiogram and on Myocardial Infarction Area in Rats with Acute Myocardial Ischemia[J];Journal of Anhui Traditional Chinese Medical College;2011-05
5 LI Ming-lei1 WANG Hua2 CHENG Ze-bin2(1Department of postgraduates,Shanxi College of TCM,Taiyuan 030024,China;2Hubei College of TCM,Wu Han 430061,China);Effect of electroacupuncture of Neiguan point on autonomic nerve,SP and NOS in AMI rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2007-08
6 GAO Jian-feng1,2,LV Feng-hua3,ZHU Chang-lian1 (1The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China; 2Physiological Department of Henan College of TCM,Zhengzhou 450008,China; 3The First Hospital Affiliated to Xinxiang Medical College,Weihui 453100,China);Effect of electroacupuncture on cell proliferation and differentiation in dentate gyrus of aged rats with focal cerebral ischemia reperfusion injury[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-07
7 LIU Cun-zhi1,SHI Guang-xia1,GUAN Li-ping2,LI Zu-guang3,YANG Xiao-min2(1Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China;2Tianjin College of Traditional Chinese Medicine,Tianjin 300193,China;3Tianjin Nankai Hospital of Traditional Chinese Medicine,Tianjin 300102,China);Effect of acupuncture on expression of NF-κB and IκB in cerebral multi-infarction rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-07
8 FENG Chun-yan1,FAN Xiao-nong2,3,ZHANG Chun-hong3,et al(1.Tianjin University of TCM;2.Laboratory of Relationship of Acupuncture Manipulation Quantification & effect· State Administration of TCM of the People's Republic of China;Key Laboratory of Acupuncture and Moxibustion· Tianjin;Laboratory of SHI Xue-min's Academic Thought;3.The First Teaching Hospital of Tianjin University of TCM,Tianjin 300193,China);Effects of Different Acupoints Acupunctured with Medium Frequency and Short Time on Cerebral Blood Flow of MCAO Rats[J];Journal of Chengdu University of Traditional Chinese Medicine;2009-04
9 Le ZHONG, Xia WANG, Xiao-He YU, Yu-Jia YANG. Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China;Long-lasting behavioral alterations in neonatal rats after hypoxic-ischemic brain damage[J];The Chinese Journal of Contemporary Pediatrics;2005-03
10 WANG Zhi-gang1,ZHANG Wei-ze2,MA Ling2,CHEN Yong-qing2,LI Tao2,SU Fang-ju3,LI Pei-hong1 1.Department of Cardiology,The Second Affiliated Hospital of Lanzhou University,Lanzhou 730050,Gansu,China 2.Department of Cardiology,General Hospital of PLA Lanzhou Military Area Command,Lanzhou 730050,Gansu,China 3.Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an 710000,Shaanxi,China;Inhibiting activation of ERK1/2 pathway improves atrial fibrosis and connexin40 remodeling in rats[J];Academic Journal of Second Military Medical University;2012-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 YUAN Lin+ 1 , YAO Da-wei+2, TANG Lei+1, HUANG Wen-hua+1, JIAO Pei-feng+1, LU Yun-tao+1, DAI Jing-xing+1, ZHANG Hui+1, HE Zhen-quan+3, ZHONG Shi-zhen+1(1Department of Anatomy,the First Military Medical University, Guangzhou 510515,China; 2Department of Anatomy, Hong Kong Chineses University, Hong Kong China; 3Guangzhou Chinese Medical University,Guangzhou 510405,China);A STUDY ON MORPHOLOGICAL BASIS OF CHINESE ACUPUNCTURE AND MOXIBUSTION FROM DIGITAL HUMAN BODY[J];Acta Anatomica Sinica;2004-04
2 $$$$ChenEryu,ShenXueyong,DangRuishan,ChengHuansheng,CaiDehen,HeWensheng,FeiLun(DepartmentofAnatomy,TheSecondMedicalUniversityofPLA,Shanghai,200433)AbastractForinvestigatingthecorelatedtissuestructurefor“conduction”inchannels,therelationshipbetweenconnec;TXARELATIONSHIPBETWEENCONNECTIVETISSUEANDACCUMULATIONOFCALCIUMWITHPOINTSONGBCHANNELBELOWHEAD[J];SHANGHAI JOURNAL OF ACUUNCTURE AND MOXIBUSTION;1998-02
3 YUAN Lin,ZHONG Shi_zhen (The First Military University of Medicine,Gongzhou510515,China);Human Auto-Testing and Modulating System——Anatomic Basis Involved in Meridianal System[J];Tianjin Journal of Traditional Chinese Medicine;2004-05
4 Guo Yi, Xu Tangping (Tianjin College of TCM) Chert Jinsheng, Zhang Chunxu, Jiang Ping (Nankai University, Tianjin);THE STUDY ON CALCIUM ION CONCENTRATION SPECIFICITY IN MERIDIAN AND ACUPOINT IN RABBIT[J];Acupuncture Research;1991-01
5 LIU Hui-rong,HUANG Zhen,WU Huan-gan. (Acupuncture and Meridian Institute,Shanghai TCM University,Shanghai 200030,China );The process of chronic pathological pains by acupuncture[J];Modern Rehabilitation;2001-21
6 LIU Zhong-hua.General Hospital of Guangzhou Command of PLA,Guangzhou 510010,China;Calcium channel and pain[J];Modern Rehabilitation;2002-12
7 Zhong Hejiang,Yang TiandeZhong Hejiang,Yang Tiande,Department of Anesthesiology,Xinqiao Hospital,Th ird Military Medical University,Chongqing 400037,China;Sodium channels in dorsal root ganglion and pain[J];Modern Rehabilitation;2003-04
8 Man Ying Xu,Wei Yang,Department of Physiology,Harbin Medical University,Harbin 150086,Heilongjiang Province,China Chun Xiao Yang 1,Tie Feng Shi 2,1 Department of Neurology,2 Department of Surgery,Second Affiliated Hospital of Harbin Medical University,Harbin 150086,Heilongjiang Province,China;Level of cholecystokinin octapeptide and mechanism of increasing acupuncture analgesia effect[J];Chinese Journal of Clinical Rehabilitation;2003-31
9 Yuan Lin, Jiao Peifeng, Tang Lei, Huang Wenhua First Military Medical University, Guangzhou 510515;Anatomical Basic of Traditional Chinese Medical Channels[J];China Basic Science;2005-03
10 JIANG Zhongli, CHEN Jiawei, ZHU Hongjun, et al.//Chinese Journal of Rehabilitation Medicine, 2003, 18(2):69-71;Effects of exercise and insulin on c-Jun NH_2-terminal kinase activity and p38 phosphorylation in skeletal muscle of rats with hyperglycemia[J];Chinese Journal of Rehabilitation Medicine;2003-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved