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《Chinese Journal of Rehabilitation Medicine》 2009-11
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Effect of acupuncture on modulation of extracellular signal regulated kinase 1/2 and P38 mitogen-activated protein kinase signal transduction pathways in subcutaneous fascia and spinal medulla of rats

JIANG Xuemei, YUAN Lin, ZHANG Xuequan, et al. School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515  
Objective: To observe the effect of acupuncture on the expressions of extracellular signal regulated kinase 1/2(ERK 1/2) and P38 mitogen-activated protein kinase(P38 MAPK) in subcutaneous fascia and dorsal horn of spinal cord of SD rats and the morphologic changes of fascia connective tissue. Method: Twenty SD rats were randomly divided into 4 groups, 5 rats in each group. Rats of acupuncture acupoint group and acupuncture non-acupoint group received hand acupuncture with twist manipulation. Rats of stretch stimulation group received acupuncture with stretch stimulation. The morphologic changes of subcutaneous fascia were observed by phase - contrast microscope. Result: Morphologic changes: fibers of subcutaneous fascia were stretched centripetally to the center of tension, the mean density of cells increased in unit area the configuration of cytoplasm and nucleus were reconstructed as long spindles with unclear boundaries under tension. Changes of signal transduction protein: the expressions of ERK1/2 and P38 MAPK increased especially in acupuncture non-acupoint group; and the location of ERK1/2 and P38 MAPK at neurocyte of spinal cord transferred from cytoplasm to nucleus after acupuncture. The expression of ERK1/2 in neurocyte didn′t enhance, while the expression of P38 MAPK enhanced after acupuncture. Conclusion: Acupuncture could up-regulate the expressions of ERK1/2 and P38 MAPK in local subcutaneous fascia. But the expressions of ERK1/2 and P38 MAPK in spinal cord were not completely coincidence with the expressions in fascia. Acupunture can regulate the nearoactivity and maybe promote the cell differentiation and proliferation of local fascia, and it′s mechanism maybe due to the modulation of ERK1/2 and P38 MAPK signal transduction pathways by destructive factors produced by mechanical stimulation of acupuncture.
【Fund】: 国家重点基础研究计划(973计划)项目(2007CB512705)
【CateGory Index】: R245.3
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