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《Chinese Journal of Rehabilitation Medicine》 2011-02
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The effects of hyperbaric oxygen therapy on neuron apoptosis and apoptosis-related genes after traumatic brain injury in rats

YAO Yanpeng,ZHANG Xinding,HAN Yanming,et al. Department of Neurosurgery,Second Clinical Hospital of Lanzhou University,Lanzhou,730000  
Objective:To investigate the relationship between the therapeutic effects of hyperbaric oxygenation (HBO) on focal brain contusion and its impacts on apoptosis and Caspase-3 and Bcl-2 of apoptosis related genes after traumatic brain injury in rats.Method:Sixty-six adult healthy male Wistar rats were randomly divided into hyperbaric oxygen treatment(HBOT) group,injury control group and sham-operated group.Application of free-fall method was employed to establish the rat model of moderate traumatic brain injury.Apoptosis of neuron cells were evaluated with TUNEL technique.The cerebral expressions of Caspase-3 and Bcl-2 were analyzed with immunohistochemical technique.Result:In traumatic penumbra area the apoptosis rates of neuronal cells in HBOT group were significantly lower than those in injury control group(P0.01).The expression of Caspase-3 in traumatic penumbra area enhanced quite obviously,following trauma;the expression of Caspase-3 in control group was obviously lower than that in HBOT group(P0.01).However,expression of Bcl-2 in traumatic penumbra area enhanced quite obviously.The expression of Bcl-2 in HBOT group was obviously better than that in control groups(P0.01).Conclusion:The effect of HBO is closely correlated with apoptosis and apoptosis related genes after traumatic brain injury,and apoptosis inhibition by HBO might be an important mechanism for the treatment of focal brain contusion after traumatic brain injury.
【CateGory Index】: R459.6
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