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《China Journal of Oral and Maxillofacial Surgery》 2012-01
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Effects of lithium on the healing of tooth extraction sockets in rats

FU Bin,ZENG Yun-ting,TANG Guo-hua.(Department of Orthodontics,Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China)  
PURPOSE: The purpose of this study was to investigate the effect of lithium on the healing of tooth extraction sockets in rats.METHODS: 20 Wistar rats were selected and subjected to left maxillary second molar extraction.All rats were randomly divided into two groups.The experimental group received daily LiCl injection intraperitoneally from 7 days before tooth extraction to 3 days after extraction.The control group was administrated the same volume of NaCl.All rats were sacrificed on 3 or 7 days after extraction.HE staining was carried out to investigate the new bone formation.BrdU was used to label the proliferative cells.The amount of proliferative cells and the volume of new bone were semi-quantified by Image-Pro Plus analysis system.The differences among the groups were analyzed by SPSS 13.0 software package.RESULTS: Mesenchymal cells proliferated in tooth extraction sockets on day 3 after tooth extraction.The number of BrdU labeled cells in the experimental group was 1.8 folds to that in the control group,which was of significant difference(P0.05).On day 7,new bone formation extended from the bottom of the sockets.The volume of new trabecular bone was 27.0%±6.5% in the experimental group,which was significantly larger than 12.7%±5.1% in the control group(P0.01).CONCLUSION: Early delivery of lithium increases the proliferation of mesenchymal cells and new bone formation in tooth extraction sockets in rats.
【Fund】: 上海市科学技术委员会基金项目(10QH1401600);; 上海市重点学科建设项目(S30206);; 上海市教育委员会基金项目(09YZ75)~~
【CateGory Index】: R782.11
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Zeng Yunting, Tang Guohua;The impact of drugs on healing and remodeling of tooth extraction sockets[J];Chinese Journal of Dental Materials and Devices;2010-02
2 LIU Hai-Xia,ZHOU Jie,XU Ji,TANG Guo-Hua.(Department of Orthodontics,College of Stomatology,Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China);β-catenin activator enhances bone regeneration during premaxillary suture expansion in rat[J];China Journal of Oral and Maxillofacial Surgery;2010-06
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Chinese Journal Full-text Database 6 Hits
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4 ZHANG Lei,CHEN Rong-Jing,TANG Guo-Hua.(Department of Orthodontics,College of Stomatology,Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology.Shanghai 200011,China);Identification of cell apoptosis during premaxillary suture expansion in rat[J];Shanghai Journal of Stomatology;2009-03
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6 HAN Lei,TANG Guo-hua.(Department of Orthodontics, College of Stomatology,Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Key Laboratory of Stomatology. Shanghai 200011, China);The nature of stretching forces on osteoblast biology in vitro[J];China Journal of Oral and Maxillofacial Surgery;2009-02
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