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《JOURNAL OF TRADITIONAL CHINESE OPHTHALMOLOGY》 1998-03
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A study about the effect of ligustrazine on the levels of endothelin1, thromboxane B2, 6ketoprostaglandin F1α, and index of hemorheology in the plasma of the patients with retinal vein occlusion

He Jianfeng1, Zhou Weiping2, Qiu Yijie3. 1 Department of Ophthalmology, Liu zhiu Renmin Hospitol, Guangxi 545001  
OBJECTIVE: To observe the effect of ligustrazine on the levels of endothelin1 (ET1), thromboxame B2 (TXB2 ), 6ketoprostaglandin F1α(6KF) and index of hemorheology in plasma of the patients with retinal vein occlusion (RVO). METHODS: Seventy six patients with RVO were treated with injection ligustrazine for twenty days. The levels of ET1, TXB2, 6KF and the index of hemorheology in plasma of the patients before and after the treatment were measured. RESULTS: The levels of ET1 and TXB2 in plasma of the patients were significantly higher than that in the control (P0001). The index of hemorheology was obviously abnormal in the patients. After treating the visual acuity of the patients was improved, the levels of ET1 and TXB2 in plasma were markedly decreased, the levels of 6KF were obviously increased. The index of hemorheology was also ameliorated. These changes were significantly difference compared with before the treatment (P001). CONCLUSION: The levels of ET1 and TXB2 in plasma were markedly decreased, the levels of 6KF were obviously increased, the index of hemorheology was also ameliorated in the patients with retinal vein occlusion treated with ligustrazine.
【CateGory Index】: R285.6
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