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《Chinese Journal of Clinical Neurosurgery》 2005-02
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Clinical Study of Curative Effect of Oxiracetam Injection on Brain Injury

ZHANG Kai, HOU Ying-zhi, ZHANG Jian-guo, et al . Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, China  
Objective To evaluate the curative effect of oxiracetam on neurological deficits as well as disturbances of memory and intelligence secondary to brain injury, and its safety. Methods Two hundred and forty patients were randomly divided into treatment group with oxiracetam and control group (receiving piracetam). The neurological deficits were evaluated by National Institutes of Health (USA) Stroke Scale (NIHSS). The disturbances of memory and intelligence were evaluated by MMSE Scale. GCS in both the groups were observed. Electrocardiogram (ECG) and laboratory examination were performed. The side effects were observed also. Results The improvement in NIHSS and MMSE were significantly better in the treatment group with oxiracetam than that in the control group. There was insignificant difference in GCS between both the groups. The side effects relative to the drugs in both the groups were not observed. ECG and laboratory examination in both the groups were significantly unchanged. Conclusions Oxiracetam can better improve the neurological deficits and disturbances of memory and intelligence secondary to brain injury compared with piracetam. The improvement in GCS produced by oxiracetam is similar to that by piracetam in the patients with brain injury.
【CateGory Index】: R651
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【References】
Chinese Journal Full-text Database 3 Hits
1 WANG Shu-zhen~(1*) CHI Zhao-fu~1 MA Lin~1 ZHANG Yong~2 DI Qing~3 HAN Zhao~4 YU Hao~5 HAN Ting~6 (1.Department of Neurology,Qilu Hospital of Shandong University,Ji-nan SHANDONG 250012,China:2.Department of Neurology,Shandong Provincial Hospital,Ji-nan SHANDONG 250021,China;3.Department of Brain Hospital of Nanjing Medical University,Nanjing JIANGSU 210029,China;4.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ZHEJIANG 325000,China;5.Department of Epidemiology and Biostatistics School of Public Health,Nanjing Medical University,Nanjing JIANGSU 210029,China;6.Shijiazhuang Pharmaceutical Group Ouyi Pharmaceutical Company,Shijiazhuang HEBEI 050051,China);A randomized double-blind controlled multicenter study with oxiracetam for injection in treatment of organic brain syndrome[J];Chinese Journal of New Drugs and Clinical Remedies;2007-04
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1 LIN Xin, SU Chen-fang, ZHANG Sai, et al . Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, China;Clinical Study of Effect of Kangrong Injection on Intracranial Pressure in patients with Brain Injury[J];Chinese Journal of Clinical Neurosurgery;2004-03
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 XU Supeng, KE Xulin, LU Zhanhong, et al;CLINICAL OBSERVATION ON KANGRONG INJECTION DECREASING INTRACRANIAL HYPERTENTION IN PATIENTS WITH CEREBRAL APOPLEXY[J];Modern Hospital;2006-06
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【Co-references】
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1 Hai li bi nu er, WANG Yin hua, ZHAO Fa guo (Department of Neurology, The First Hospital of Peking University, BEIJING 100034, China);Randomized double-blind controlled study of oxiracetam vs piracetam in treatment of vascular dementia[J];Chinese Journal of New Drugs and Clinical Remedies;2003-11
2 WANG Shu-zhen~(1*) CHI Zhao-fu~1 MA Lin~1 ZHANG Yong~2 DI Qing~3 HAN Zhao~4 YU Hao~5 HAN Ting~6 (1.Department of Neurology,Qilu Hospital of Shandong University,Ji-nan SHANDONG 250012,China:2.Department of Neurology,Shandong Provincial Hospital,Ji-nan SHANDONG 250021,China;3.Department of Brain Hospital of Nanjing Medical University,Nanjing JIANGSU 210029,China;4.The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ZHEJIANG 325000,China;5.Department of Epidemiology and Biostatistics School of Public Health,Nanjing Medical University,Nanjing JIANGSU 210029,China;6.Shijiazhuang Pharmaceutical Group Ouyi Pharmaceutical Company,Shijiazhuang HEBEI 050051,China);A randomized double-blind controlled multicenter study with oxiracetam for injection in treatment of organic brain syndrome[J];Chinese Journal of New Drugs and Clinical Remedies;2007-04
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【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 LIU Peng1,LI Jianhe2, CAO Junhua2, LUO Xia2 (1.Dept. of Pharmary, Changlian Hospital of Yueyang,Yueyang 414012,China;2.Dept. of Pharmary,Second Xiangya Hospital,Central South University,Changsha 410011,China);Bacterial endotoxin test for oxiracetam injection[J];China Modern Medicine;2009-12
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1 XL Jiao,DH Yu,AQ Zou and YQ Lou(Department of PharmacologyBeijing Medical UmiversityBeijing 100083);METHODOLOGICAL STUDY ON THE DETERMINATIN OF OXIRACETAM CONCENTRATION IN SERUM AND URINE BY HPLC[J];ACTA PHARMACEUTICA SINICA;1994-08
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