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Clinical Study of Curative Effect of Oxiracetam Injection on Brain Injury

ZHANG Kai, HOU Ying-zhi, ZHANG Jian-guo, et al . Department of Neurosurgery, Beijing Tiantan Hospital, Beijing 100050, China  
Objective To evaluate the curative effect of oxiracetam on neurological deficits as well as disturbances of memory and intelligence secondary to brain injury, and its safety. Methods Two hundred and forty patients were randomly divided into treatment group with oxiracetam and control group (receiving piracetam). The neurological deficits were evaluated by National Institutes of Health (USA) Stroke Scale (NIHSS). The disturbances of memory and intelligence were evaluated by MMSE Scale. GCS in both the groups were observed. Electrocardiogram (ECG) and laboratory examination were performed. The side effects were observed also. Results The improvement in NIHSS and MMSE were significantly better in the treatment group with oxiracetam than that in the control group. There was insignificant difference in GCS between both the groups. The side effects relative to the drugs in both the groups were not observed. ECG and laboratory examination in both the groups were significantly unchanged. Conclusions Oxiracetam can better improve the neurological deficits and disturbances of memory and intelligence secondary to brain injury compared with piracetam. The improvement in GCS produced by oxiracetam is similar to that by piracetam in the patients with brain injury.
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