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《Chinese Journal of Clinical Neurosurgery》 2007-01
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Effect of Glucocorticosteroid on Plasma Levels of TNF-α and IL-1 β in Patients with Severe Traumstic Brain Injury

HE Jia-yi*, WEI Jing-wang, ZHANG Jian-sheng. *Department of Neurosurgery, The Second Affiliated Hospital, Lanzhou University, Lanzhou Gansu 730030, China  
Objective To investigate the effect of glucocorticosteroid on plasma level of TNF-α and IL-1β in the patients with severe traumatic brain injury (TBI). Methods Forty-two patient with severe TBI were randomly divided into gucocorticosteriod treatment group (20 case) and control group (22 case). Each patient in the treatment group were given 10 mg dexamethasone every day for 7 days. The patients in the control group were given the same treatment as ones in all the treatment group except for dexamethasone. TNF-α and IL-1β in the plasma were detected by ELISA 1, 2, 7 and 14 days after the TBI in all the patients and 15 healthy people. Results The plasma levels of TNF-α and IL-1β in the control group 1, 2,7 and 14 days after TBI were significantly higher than those in the normal group (P0.01). The plasma levels of TNF-α and IL-1β in the treatment group 1 and 2 days after TBI were significantly higher than that in the normal group (P0.01). The plasma level of TNF-α and IL-1β 7 and 14 days after TBI in the treatment group were significantly lower than those in the control group (P0.01) and insignificantly higher than those in the normal group (P0.05). Conclusions Glucocorticosteroid is of obviously tardy effect on decreasing plasma levels of TNF-α and IL-1β in patients with TBI, and it can not eliminate detrimental effect originated by TNF-α and IL-1β in earlier period of TBI. Furthermore the low plasma levels of TNF-α and IL-1β caused by glucocorticosteroid did not exert neuroprotective effect during convalescent period. Maybe the effect of glucocorticosteroid on TNF-α and IL-1β is one of disadvantage factors in the patient with TBI.
【CateGory Index】: R651.15
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【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 QU Qiang,SHI Zhong△ (Department of Emergency,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Changes of TNF-α,IL-1β and cortisol in serum and hepatic GR following severe traumatic brain injury[J];Chongqing Medicine;2007-18
2 DE-SHENG PAN*, WEI-GUO LIU#, XIAO-FENG YANG*,1, AND FEI CAO* *Department of Neurosurgery, The First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, Zhejiang, China; #Department of Neurosurgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, Zhejiang, China;Inhibitory Effect of Progesterone on Inflammatory Factors After Experimental Traumatic Brain Injury[J];生物医学与环境科学(英文版);2007-05
3 LEI Peng ZHANG Xing-chao PENG Long-feng Department of Neurosurgery,General Hospital of Lanzhou Military Command,Lanzhou 730050, China;Effect of erythropoietineffects on protein expressions of IL-1βand S100βin rats with severe brain injury and hemorrhagic shock[J];Chinese Journal of Trauma;2007-09
4 LU Chuan, SUN Jun, CHEN Xiandong, et al. Wenzhou Second People's Hospital, Wenzhou 325000, China;Changes in levels of cerebrospinal fluid TNF- α、IL- 6 in patients with acute brain trauma[J];Zhejiang Journal of Traumatic Surgery;2008-03
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