Full-Text Search：
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《中国药理学报(英文版)》 1994-02
Add to Favorite Get Latest Update

Effects of puerarin on cat vascular smooth muscle in vitro

WANG Lei-Yi, ZHAO Ai-Ping, CHAI Xiang-Shu (Department of Physiology, Shandong Academy of Medical Sciences, Ji-nan 250001, China)  
Puerarin is an isoflavone compound isolated from Pueraria lobata (Willd). This study characterized the vascular action of puerarin in order to more clearly elucidate its pharmacological activities. Helically cut strips of cat femoral veins and renal arteries were suspended in an organ chamber filled with Krebs bicarbonate solution for measurement of isometric force development. In the cases of femoral veins and renal arteries isoproterenol (0.01 μmol·L-1 -0. 1 mmol·L-1) caused relaxation of methoxamine-induced contraction (0. 01 mmol·L-1) in a concentration -related manner. Puerarin (0.01 - 0. 1 mmol·L-1) inhibited the relaxation response to isoproterenol in a concentration-response fashion. Propra-nolol (0. 1 - 1 μmol·L-1) inhibited the isopro-terenol-induced relaxation too. Puerarin (0. 1 mmol ·L-1) did not alter the relaxation response to nitroglycerin (1 μmol·L-1). These results indicated that puerarin acted as a beta-adrenoreceptor antagonist in isolated arteries and veins.
【Key Words】： puerarin isoflavones isopro- terenol propranolol nitroglycerin femoral vein renal artery drug dose-response rela- tionship vascular smooth muscle
【CateGory Index】： R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 XU Lingfeng1 ,CHEN Qiang1,3 ,YUAN Bo1,CHI Bo1,SHEN Jian1,2 ,LIN Sicong1(1 School of Chemistry and Chemical Engineering,Nanjing University;Research Center of Surface and Interface ChemicalEngineering & Technology,Jiangsu Province,Nanjing 210093;2 Jiangsu Engineering Research Center for Bio-medical FunctionMaterials,Nanjing Normal University,Nanjing 210097;3 High-Tech Research Institute of Nanjing University,Changzhou 213164);Synthesis and Characterization of Macromolecular Prodrugs of Puerarin[J];Materials Review;2008-10
2 MA Bao-hua,ZHANG Li,QU Xian-cheng(Qingdao Central Hospital,Shandong Qingdao 266042,China);Clinical Observation of the Effects of Puerarin Injection on Angina Pectoris[J];Hebei Medicine;2006-02
3 Wang Wei (王 伟), Zhang Tao (张 涛), Zhao Mingjing (赵明镜), et al. (The Affiliated Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100070);The Interaction of Five Chinese Herbs Flavones on the Apoptosis of Vascular Smooth Muscle[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;2000-04
4 Wang Jinhong, Li Hongjun, Gao Er, et al Department of Applied Pharmacology ,Weifang Medical College,Weifang,261042;EFFECT OF PUERARIN、PHOSPHOLIPID AND THEIR COOPERATION ON HYPERLIPIDEMIA RABBIT'S HEMORHEOLOGY[J];JOURNAL OF WEIFANG MEDICAL COLLEGE;1998-04
5 LI Guohui,CHEN Hui;Therapeutic Effect of Puerarin Injection Combined with Western Medicine for Hypokinesia Type and Rigid Type Parkinson's Disease:A Report of 30 Cases[J];Journal of New Chinese Medicine;2010-09
6 WANG Zhen1, CHAI Qiang2, LIU Zhi-xiang2, LIU De-xiang3, CHEN Lian-bi1 (1.Institute of Physiology, School of Medicine, Shandong University, Jinan 250012, Shandong, China; 2. Department of Physiology, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, China; 3.Institute of Medical Psychology, School of Medicine, Shandong Univevsity, Jinan 250012, Shandong, China);Ca~(2+)-activated Cl~- channels contribute to norepinphrine-induced contraction of rat tail artery[J];Journal of Shandong Univenity(Health Scicnes);2005-04
7 Wang Shijun, Shi Renhua, Ji Guangchen, et al/Traditional Chinese Medical University of Shandong, Jinan 250014;Effect of Puerarin, Tetramethyl Pryazine and Injection of Salvia Miltiorrhiza Bunge on Pial Microcirculation in Rabbits[J];CHINESE JOURNAL OF MICROCIRCULATION;1999-04
8 Zhang Hua1, Sun Shu-hong1, Ma Lan-xiang1, Yang Xing-chang1, Jia Guo-liang2, 1Heart Center, Shaanxi General Corps Hospital of Chinese People's Armed Police Forces, Xi'an 710054, Shaanxi Province, China; 2Department of Cardiology, Xijing Hospital, Fourth Military Medical University of Chinese PLA, Xi'an 710032, Shaanxi Province, China;Effect of puerarin on the expression of inward rectification of kalium current ion channels in Xenopus oocytes[J];Chinese Journal of Clinical Rehabilitation;2005-43
9 ZHANG Hua1,ZHOU Jun2,ZHANG Li1,YANG Xing-chang1,MA Lan-xiang1 (1.Department of Cardiology,Shaanxi Provincial Corps Hospital,Chinese People′s Armed Police Forces,Xi′an 710054,Shaanxi,China;2.Department of Pharmacology,School of Medicine,Xi′an Jiaotong University,Xi′an 710032,Shaanxi,China);Effect of Puerarin on currents in rat′s ionic channel of cardiac myocytes[J];Chinese Heart Journal;2007-05
10 YAN Han-Ying; ZHU Yan-Qin; WU Zheng-Hong; CHEN Guang-Xin (Accepted for publication Aug 25，1998 Fron the Research Center of Ocular Pharmacology,Jiangsu Provincial Institute of Materia Media, Nanjing 210009,China YAN Han－Ying，ZHU Yan-Qin；China Pharmac;Puerarin eyedrops: action of reducing intraocular pressure and the concentration in aqueous humor[J];RECENT ADVANCES IN OPHTHALMOLOGY;1999-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 CHENG Min1,JIANG Ke-hai2,HUANG Ping3(1.Huaibei Institute for Food and Drug Control,Huaibei 235000;2.Chuzhou Institute for Food and Drug Control,Chuzhou 239300;3.Anhui Institute for Food and Drug Control,Hefei 230061,China);1012 cases of adverse reactions/event of shengmai injections[J];Anhui Medical and Pharmaceutical Journal;2011-02
2 Wang Xiaohong,Hu Huimei (Department of internal medicine,Anhui rehabilitation hospital,Hefei 230031);EFFECT OF PUERAIN ON HEMORHEOLOGICS OF CORONARY HEART DISEASE AND ITS EFFECTIVENESS EVALUATION[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;1999-03
3 ZHANG Lian ru ZOU Guo lin YANG Tian ming (College of Life Sciences,Wuhan,University,Wuhan 430072);Studies on Extraction of Water-soluble Polysaccharides and the Function of Cleaning Oxygen Free-radical Function of Ephedra[J];AMINO ACIDS & BIOTIC RESOURCES;2000-03
4 YAN Gui-long (Huaiyin Teacher’s College, Huaiyin 223001, China);The Extraction and Purification Technology for Puerarin[J];Amino Acids & Biotic Resources;2004-03
5 QU JINGXIAN (Department of Physiology, Nantong Medical College);PROGESTERONE RECEPTORS IN THE RAT UTERUS DURING THE IMPLANTATION PHASE OF PREGNANCY (DAYS 1-6)[J];Acta Zoologica Sinica;1985-02
6 ZHANG RONG-QING HAN ZHENG-KANG CHEN JIE ZHANG CHONG -LI, (Lab of Animal Physiology and Biochemistry, Nanjing Agric. Univ., Nanjing 210095) (Institute of Zoology, Chinese Academy of Sciences, Beijing 100080);EFFECTS OF DAIDZEIN ON IMMUNE FUNCTION AND GH、PRL、SS LEVELS OF SERUM AND COLOSTRUM IN SOWS[J];Acta Zoologica Sinica;1995-02
7 ZHANG RoNG-QING HAN ZHENG-KANG CHEN JIE ZHANG CHONG-LI (Lab of Animal Physicly and Biochemistry, Nanjing Agric, Univ, Nanjing 210095) (Institute of Zoology, Chinese Academy of Sciences, Beijing 100080);EFFECTS OF DAIDZEIN ON MAMMARY GLAND DEVELOPMENT IN RATS[J];Acta Zoologica Sinica;1995-03
8 PEI Lingpeng, LI Wen\|sa, TANG Fenfang(College of Applied Sciences and Humanities of Beijing Union University,Beijing\ 100083, China);Study on Extraction of Total Flavone From Pueraria Lobata Ohwi by Ultrasonic Wave[J];Journal of Beijing Union University;2003-03
9 Wu Guixin;Wang Feng;Wu Yune;Feng Weiquan(Graduate Department, BUPE, Beijing 100084Teaching and Research Section of Exercise Biochemistry, BUPE, Beijing 100084);Exercise and Nitric Oxide in Skeletal Muscles[J];Journal of Beijing University of Physical Education;1999-03
10 YE Ping1,WANG Xiang-gui1,HUANG Chen2,XU Shu-yi2,YE Qian2,ZHANG Li1(1Gynecology Department of Zhejiang Provincial Hospital of TCM,Hangzhou 310006,China;21st Clinical Medical School of Zhejiang University of TCM,Hangzhou 310053,China);Effect of puerarin on uterine estrogen receptor α expression in ovariectomized rats[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-07
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 TAN Jia-hua et al(The first Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang,Guizhou 550001);Determination of Puerarin and Paeoniflorin in Yanbao I Capsule by HPLC[J];Journal of Anhui Agricultural Sciences;2012-12
2 WEI Jian-fei,LIU Chao,ZHANG Jin-hao,LIU Ting-yue,NIE Su-shuang(School of Materials Science and Engineering,Beijing Institute of Fashion Technology,Beijing 100029,China);Study on Purification of Puerarin by Ion Exchange Fiber with Orthogonal Array[J];Journal of Beijing Institute of Clothing Technology(Natural Science Edition);2009-02
3 ZHOU Dong-ju ZHAO Hui-ying YANG Ying-lu(College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China);The absorption of puerarin in rats' intestines[J];Journal of Beijing University of Chemical Technology(Natural Science Edition);2006-05
4 SHEN Xiao-jun,WEI Yan,HE Hang(Henan University of TCM,Zhengzhou 450008,China);Effect of icariin on expression of glucose regulated protein78 in atherosclerosis tissue[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-05
5 SUN Hui TIAN Wei ZHANG Hui LIU Hongxia FAN Qianqian DIAO HuilingCollege of Basic Sciences,Binzhou Medical University,Binzhou 256603;Effects of puerarin on constractive activity of small intestine smooth muscle in alcoholism rabbit[J];Journal of Binzhou Medical University;2009-05
6 GONG Zhi-gang1,SHI Xiang-qun2,QIAN Yi-qing1(1.College of Physical Education,Jiangxi Normal University,Nanchang 330027,China;2.Pharmaleutical Laboratory of Medical College,Jiujiang University,Jiujiang Jiangxi 332000,China);Effect of Puerarin on Exercise Performance and Serum Free Radical Metabolism in Trained Rats[J];Journal of Jiangxi Normal University(Natural Sciences Edition);2008-01
7 XU Lingfeng1 ,CHEN Qiang1,3 ,YUAN Bo1,CHI Bo1,SHEN Jian1,2 ,LIN Sicong1(1 School of Chemistry and Chemical Engineering,Nanjing University;Research Center of Surface and Interface ChemicalEngineering & Technology,Jiangsu Province,Nanjing 210093;2 Jiangsu Engineering Research Center for Bio-medical FunctionMaterials,Nanjing Normal University,Nanjing 210097;3 High-Tech Research Institute of Nanjing University,Changzhou 213164);Synthesis and Characterization of Macromolecular Prodrugs of Puerarin[J];Materials Review;2008-10
8 Zheng Wangqiao,Song lihua,Li haiju,et al.Department of Pharmacology,Changzhi Medical College;The Effects of Puerarin on Blood Glucose and Blood Lipid in Type Ⅱ Diabetic Rats[J];Journal of Changzhi Medical College;2009-02
9 Cui Xiu-ling~1, Wang Yuan-zheng~2, Liu Xiao-jian~3(~1The Affiliated Third Hospital of Liaoning Medical University,Jinzhou 121001,China;High-ranking medical treatment service center, The Affiliated FirstHospital of Liaoning Medical University,Jinzhou 121001,China;Department of pharmacology,Liaoning Medical University,Jinzhou 121001,China);The Effect of Puerarin on the Glycometabolism, Lipid Metabolism and Renal Function of Diabetic Rats[J];Chinese Journal of Medicinal Guide;2009-10
10 WU Hai-qin, WANG Hu-qing, CHENG Hong-xue, ZHANG Gui-lian, ZHAN Shu-qin Department of Neurology, Second Hospital Affiliated to Xi'an Jiaotong University College of Medicine, Xi'an 710004, China;Expression of hypoxia inducible factor-1α in different brain regions in aged rats[J];Journal of Southern Medical University;2008-10
China Proceedings of conference Full-text Database 1 Hits
1 ;Synthesis and in vitro evaluation of the hemolytic property of the puerarin prodrug[A];[C];2009
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved