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《中国药理学报(英文版)》 1995-03
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Effects of quercetin on aggregation and intracellular free calcium of platelets

XIAO Dong, GU Zhen-Lun(Department of Pharmacology, Suzhou Medical College, Suzhou 215007, China) BAI Jian-Ping (Department of Pharmacology, Datong Medical College, Datong 037008, China) WANG Zhong (.Department of Pharmacology, the Chinese Academy of Medical Sciences, Beijing 100005, China)  
AIM:To study the effects of Que on the in-traplatelet free calcium concentration and the effects of calcium on the inhibition of platelet aggregation by Que. METHODS: Using Quin-2 fluorescence technique. RESULTS: Que inhibited the platelet aggregation and the rise of [ Ca2+]i induced by thrombin in platelets. The values of IC50 and 95 % confidence interval were 146. 2 (92- 4 - 231. 3) and 78.5 (49.5-124.4)umol.L-1, respectively. The inhibitory effects of Que on platelet aggregation induced by thrombin were reduced by adding calcium to the medium, and Que had no effect on thrombin-induced internal Ca2+ release from dense tubular system. CONCLUSION: The inhibitory effects of-Que on aggregation and the rise of [Ca2+ ]; in platelets was mainly due to an inhibition of Ca2+ influx.
【Key Words】： quercetin thrombin platelet aggregation calcium
【CateGory Index】： R96
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