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《Chinese Journal of Convalescent Medicine》 2007-10
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Effect of Oxymatrine in treatment of chronic hepatitis B

Jiang Mei,Yin Shusheng,Jian Qiang,et al  
Objective To observe the effect of oxymatrine in treatment of chronic hepatitis B.Methods 248 patients with chronic hepatitis B were randomized into three groups according to the levels of ALT.Each group was randomized into therapeutic group and control group. The all groups were treated with protective liver therapy. The therapeutic groups were added with oxymatrine,600mg,i.v,drip,once daily. The therapeutic course was three months. At the end of one treatment month and three treatment month,the HBsAg negative rate,HBeAg negative rate anti-HBe positive rate and HBV-DNA negative rate were examined.Results HBeAg negative rate,anti-HBe positive rate and HBV-DNA negative rate in therapeutic groups were higher than in the control groups (P0.05,P0.01). HBsAg negative rate in the therapeutic groups was higher than in the control groups,but it was not statistically significant (P0.05). Conclusion Oxymatrine has the good effect in treatment of chronic hepatitis B.
【CateGory Index】: R259
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 YUAN Cai, LU Shi-Qi and YAO Xian (Department of Pharmacology, Capital Institute of Medicine, Beijing);EFFECTS OF OXYMATRINE ON THE ANTITUMOR ACTIVITY AND TOXICITY OF CYCLOPHOSPHAMIDE IN MICE[J];Acta Pharmaceutica Sinica;1987-04
2 Chen Fuxiang; Liu Jingxing; Lu Deyuan(Department of Microbiology, Shanghai Second Medical University, 200025);The Effects of Sophora Flavescens Alkaloids (SFA) on Coxsackie Virus B3(CVB3)in Vitro and a Preliminary Study of Its Mechanism[J];CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY;1995-02
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 Zhang Fengling,Tang Yong,Zhang Jingmei Zhengzhou Yonghe Pharmaceutical Corp.Ltd.;Advance in Research into Mechanism and Pharmaceutics of Matrine and Kurarinone[J];Journal of Henan College of Traditional Chinese Medicine;2004-03
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