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Study on effects of NO on hepatic injury of cirrhotic rats with TPN

LIANG Lijian,LUO Shimin.Department of Hepatobiliary Surgery,the First Affiliated Hospital of Sun Yat-Sen University of Medical Sciences,Guangzhou 510080  
Objective To investigate the effects of nitric oxide (NO) on further hepatic injury of cirrhotic rats with total parenteral nutrition (TPN). Methods 26 cirrhotic rats are divided into four groups randomly:TPN group ( n =7),TPN+L-Arg group ( n =6),TPN+L-NAME group ( n =6) and TPN+L-Arg+L-NAME group ( n =7).Liver function,hepatic triglycerin (TG) and cholesterol (CHO),the level of serum and liver NO,liver nitric oxide synthase (NOS) activity were measured.β-NADPH diaphorase statining and histologic changes of the liver were observed. Results All animals survived but one rat died of pneumonedeman in TPN group,TPN+L-NAME group and TPN+L-Arg+L-NAME group respectively.Compared with TPN group,In the TPN+L-Arg group,the level of serum and liver NO were increased significantly ( P 0.05),however,serum AST was decreased significantly ( P 0.05) but ALT was not,liver TG was decreased significantly ( P 0.05) and the degree of fatty degeneration in the liver was lessened.In the TPN+L-NAME group,the level of serum and liver NO were decreased significantly ( P 0.05),however,serum AST and ALT were increased significantly ( P 0.05),the level of liver TG was increased significantly ( P 0.05).Serum ALB,A/G ration and liver NOS activity had not significantly changes among all groups.The degree of β-NADPH diaphorase staining was ++. Conclusions NO may play a protective role in further liver injury of cirrhotic rats with TPN.
【CateGory Index】: R459.3
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