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The model of gut mucosa barrier injury by abdominal radiation in rats

DONG Guanglong, LIU Xiaoling, WANG Weizhong. Department of Gastroenterological Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032  
Objective To investigation the right dose for gut mucosa barrier damage model by abdominal radiation(AR) according to the clinical research request. Methods Male SD rats were subjected to an single dosage of 8.5 or 9.5Gy 60 Co AR from the sternen xyphoid to the pubis. The results were analysed according to bacterial culture, light microscope, electric microscope and EMIAS medical colorful image processing and analysis system. Results The mortality of this model at 4th day was approximately 33.4%, and it created a reproducible histological injury which was associated with bacterial translocation to the mesenteric lymph nodes. Conclusions The dose of 9.5Gy was to create a model for research on the therapy of damaged gut mucosa barrier as in radiation enteritis.
【CateGory Index】: R14
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