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《Chinese Journal of Clinical Nutrition》 2005-04
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Effect of Protein Formula with Lower Natrium and Lower Phosphorum on Patients with Chronic Renal Failure

Han Ting, Hu Tong-jie, Geng San-san, Liu Xiao-li, Cai Dong-lian (Department of Clinical Nutrition, Changhai Hospital, Second Military Medical University, Shanghai 200433, China)  
Objective To study the effect of Shengjia, a specialized protein formula with lower natrium and lower phosphorum, in patients with chronic renal failure (CRF). Methods A prospective, randomized, and double-blind clinical trial was performed. Sixty patients who were receiving dialysis with an average age of (48.3 卤17.4) years, were randomly divided into the therapy group (receiving Shengjia 0.8 kg/d) and the control group (receiving normal diet). The index related to nutrition were monitored before and after study. Result All patients completed the whole study course without obvious adverse events. Before study, malnutrition existed in 53.5% of patients in the therapy group and in 54.7% patients in the control group. After study, both groups were improved but not significant. Before and after study, weigh, mid-arm muscle circumference (MAMC), and triceps skin fold thickness (TSF) had no significant changes between these two groups (P > 0.05). Compared with the control group, ALB and PA except Hb in the therapy group were significantly increased (P < 0.05). Bun, Ccr in two group were significantly decreased after study (P < 0.01). Before study, all patients had poor essential amino acid and histidine profile. After study, branched-chain amino acid, including leucine, isoleucine, and valine increased remarkably (P<0.01), and threonine, tyrosine, and histidine also significantly increased too (P < 0.05), while other amino acids had no significant changes. Conclusion The specialized protein fonnula with lower natrium and lower phosphorum can greatly improve the protein level in CRF patients.
【CateGory Index】: R692.5
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