Effects of dexmedeomidine on oxidative stress in patients received one-lung ventilation in video-assisted thoracoscopic surgery
QU Yu-lian;HE Qing-quan;GONG Yan;YANG Hai-feng;CHEN Jian-shu;CHEN Hong-xia;Department of Anesthesiology,the 2nd Hospital of Wenling;Clinical Laboratory,the 2nd Hospital of Wenling;
【Objective】To discuss the effects of dexmedetomidine on oxidative stress in patients received OLV in VATS. 【Methods】42 patients were divided into control group and treatment group evenly and randomly. Treatment group received extra i.v. treatment of dexmedetomidine during the process of anaesthetization. Serum and lung tissue from patients were collected. Blood gas and serum levels of CRP, MDA and T-AOC were analyzed before and 30 min, 60 min after OLV. Levels of XOD, SOD, MPO and CAT were also assessed in lung homogenate.【Results】 Compared with control group, PaO2 /FiO2 was increased significantly in treatment group at 60 min after OLV(P 0.05); Serum levels of CRP and MDA decreased while level of T-AOC increased significantly at 60 min after OLV in treatment group than in control group(P 0.05); Levels of XOD and MPO decreased while levels of SOD and CAT increased significantly in treatment group than in control group in lung homogenate(P 0.05).【Conclusion】Degree of oxidative stress could be alleviated by dexmedetomidine by improving oxygenation level during OLV in patients received treatment of VATS.
【CateGory Index】： R614