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《China Dairy Cattle》 2013-01
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Molecular Detection of Bovine Leukocyte Adhesion Deficiency (BLAD) in Holstein Cattle of Beijing

LI Yan-hua1,ZHU Yu-lin1,ZHANG Sheng-li2,XUE Jian-hua1,LU Xiao-qing1,DU Xin-yue1,QIAO Lu1(1.Beijing Dairy Cattle Center,Beijing 100192;2.College of Animal Science and Technology,China Agricultural University,Beijing 100193)  
Bovine leukocyte adhesion deficiency(BLAD) is an autosomal recessive disease caused by A→G mutation in the CD18 gene.The disease is characterized by greatly reduced expression of the heterodimeric β2 integrin adhesion molecules on leukocytes,resulting in multiple defects in leukocyte function and significant deficits on performance traits in Holstein cattle.In this study,DNA samples from Holstein bulls(n=246) and cows(n=409) in Beijing district were detected by PCR-SSCP.BLAD-carrier rates in Holstein bulls and cows were 0.81% and 3.91%,and their gene frequencies were 0.21% and 1.95%,respectively.Our pedigree studies of the carrier cattle in this experiment revealed that the mutation inherited from Osborndale Ivanhoe bull(USA.1189870,BL)which have many progeny in China.Although the elimination of BLAD-carrier bulls from the Holstein would be the most efficient method to control this genetic disorder,many BLAD-carrier bulls are still listed commercially for AI in China.Monitoring the prevalence of BLAD-carriers in random selected herds may be helpful in judging the effectiveness of the BLAD-control program.
【Fund】: 农业科技成果转化资金项目(2010GB2A000006);; 北京市科技计划项目(D121100003312003)
【CateGory Index】: S823.3
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 CHU Qin1,2,ZHANG Yi1,SUN Dong-Xiao1,YU Ying1,WANG Ya-Chun1,ZHANG Yuan1 1.College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;2.Institute of Animal Husbandry and Veterinary Medicine,Beijing Academy of Agriculture and Forestry Sciences,Beijing 100097,China;Identification of the complex vertebral malformation gene in Chinese Holstein and its association with dairy performance traits[J];遗传;2010-07
2 MA Jin-Zhu1, CUI Yu-Dong1, 2, ZHU Zhan-Bo2, CAO Hong-Wei1, PIAO Fan-Ze2 (1. College of Life Science and Biotechnology, Heilongjiang August First Land Reclamation University, Daqing 163319, China; 2. College of Animal Science and Veterinary Medicine, Heilongjiang August First Land Reclamation University, Daqing 163319, China);Investigation on Bovine Leukocyte Adhesion Deficiency[J];遗传;2006-10
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 LIANG Ruo-bing;ZHAO Xiao-lin;SUN Dong-xiao;ZHANG Yi;ZHANG Sheng-li;WEN Fu-yong;College of Animal Science and Technology,China Agricultural University;Miyun County Agriculture Bureau;;Identification of Complex Vertebral Malformation(CVM) Carriers in Holstein Cows from Miyun Farms in Beijing[J];中国奶牛;2015-Z3
2 TANG Shao-qing;LIANG Ruo-bing;YUN Peng;YANG Yu-ze;XIAO Wei;SUN Dong-xiao;Beijing Municipal Animal Husbandry General Station;College of Animal Science and Technology, China Agricultural University;;Identification of Complex Vertebral Malformation(CVM) Carriers in Holstein Cows from Suburban Farms in Beijing[J];中国奶牛;2014-Z4
3 LI Yan-hua1,ZHU Yu-lin1,ZHANG Sheng-li2,XUE Jian-hua1,LU Xiao-qing1,DU Xin-yue1,QIAO Lu1(1.Beijing Dairy Cattle Center,Beijing 100192;2.College of Animal Science and Technology,China Agricultural University,Beijing 100193);Molecular Detection of Bovine Leukocyte Adhesion Deficiency (BLAD) in Holstein Cattle of Beijing[J];中国奶牛;2013-01
4 YU Ying,DENG Yi-Ni National Engineering Laboratory for Animal Breeding & Key Laboratory of Agricultural Animal Genetics and Breeding,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;Bovine disease-related DNA mutations and their genetic control strategies in breeding for disease resistance[J];遗传;2012-10
5 ZHOU Li1,2,JIA Guang-le1,ZHANG Ying2,HAN Xue-qing1,LIN Xiang-mei1(1.Chinese Academy of Inspection and Quarantine,Beijing 100121,China; 2.College of Animal Science and Technology,Shanxi Agricultural University,Taigu 030801,China);Progress on the Study of the Test Methods for Bovine Leukocyte Adhesion Deficiency(BLAD)[J];中国畜牧兽医;2012-02
6 Ma Jinzhu1,Song Baifen1,Wang Beiyan1,Li Xiaodong2,Cao Hongwei1,Zhu Zhanbo1,Cui Yudong1(1.Heilongjiang Bayi Agriculture University,Daqing 163319;2.Heilongjiang Animal Breeding Center);Investigation on Bovine Leukocyte Adhesion Deficiency in Breeding Oxen[J];黑龙江八一农垦大学学报;2011-05
7 FAN Xue-hua~1,ZHANG Yi~1,SUN Dong-xiao~1,SHI Wan-hai~2,CHEN Shao-hu~3,GONG Wei-jia~4,ZHANG Sheng-li~1,ZHANG Yuan~1 (1.College of Animal Science and Technology,China Agricultural University,Beijing 100193; 2.Beijing Dairy Cattle Center,Beijing 100192;3.Data center of China Dairy Association,Beijing 100192;4.Genes Diffusion);Molecular Detection of BLAD Alleles in Chinese Holstein Bulls and Pedigree Analysis of the Carriers[J];中国奶牛;2011-08
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Hong-Mei, LI Jian-Bin, HOU Ming-Hai, WANG Chang-Fa, LI Qiu-Ling, ZHONG Ji-Feng Dairy Cattle Center of Shandong Academy of Agricultural Sciences, Ji’nan 250100, China;The development and application of method for detecting bovine complex vertebral malformation[J];遗传;2008-09
2 Shan Xuesong, Zhang Yuan, Li Ning ( College of Animal Science and Technology ,China Agricultural Univer sity,Beijing 10094; National Laboratory for Agro-Biotechnology,China Agricultural University,Beijing 100094);Partial Cloning and Analysing of Weaver Gene in Xinjiang Brown Cattle[J];农业生物技术学报;2000-03
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