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《Acta Laboratorium Animalis Scientia Sinica》 2004-03
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Pharmacodynamic Research of WULONG KANGAI on Transplantable Carcinomas in Mice

LI Chun-hai,LIU Ya-qian,XIE Zhong-chen,YANG Geng-lu,CHEN Hua (Central Animal Experimental Laboratory, General Hospital of PLA, Beijing 100853, China)  
Objective To observe the effect of WULONG KANGAI-a new drug of Chinese traditional medicine-on 4 transplantable carcinomas in mice and the side effects it shows during the test. Method Acute toxicity test of WULONG KANGAI in mice was performed first, and 3 doses of the new drug were chosen for each pharmacodynamic research then. Mice transplantable tumors Lewis lung tumor, P 388 leukaemia, S 180 sarcoma and H 22 hepatoma were used in the formula pharmacodynamic tests. 15 haematological parameters and relative weights of spleens and thymuses of mice were measured in a Lewis lung tumor treatment test. Results and Conclusion WULONG KANGAI showed significant effective in treating Lewis and P 388 tumors with doses of 10,25,40 g/kg·d and in treating S 180 and H 22 tumors with doses of 15,30,50 g/kg·d. And well correlations were showed between doses and effectiveness in the tests. The results also revealed that the new drug might be harmful to hematopoietic system and immune system.
【CateGory Index】: R73-36
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