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《Acta Laboratorium Animalis Scientia Sinica》 2007-04
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Comparison of Three Types of One-Lung Ventilation Models in Rabbits

YOU Zhi-jian,YAO Shang-long,LI Jin(Department of Anesthesiology,Xiehe hospital,Tongji Medical College,HuazhongUniversity of Science and Technology,Wuhan 430022,China)  
Objective The purpose of this study was to compare three types of one-lung ventilation(OLV) models in rabbits.Methods 30 rabbits weighing 2.3±0.2 kg were anesthetized with ketamine(25 mg/kg i.m.) and were ventilated via tracheotomy tubes at a rate of 40/min with a tide volume of 10 mL/kg with pure oxygen and divided randomly into three groups.In group A(n=10) OLV was carried out by a double-lumen endotracheal tube made by ourself.In group B thoracotomy was performed and the left main bronchus was completely clamped with a clip,so OLV was carried out.In group C tracheotomy tube was pushed into the right main bronchus to perform OLV.The first time and overall success rates,the time from tracheotomy beginning to OLV beginning and volume of bleeding were recorded.The rabbit trachea was measured.Results In group A the first time and overall success rates were higher than those in group B and C.The numbers of rabbits in the three groups coming into experiment were 10,6 and 8,respectively.In group A the time from tracheotomy beginning to OLV beginning was significantly shorter than that of group B and C(P0.01).Compared with group B the bleeding volume was significantly lower than that in group A P0.01).Conclusion The rabbit model of OLV generated by the artificial double-lumen endotracheal tube is convenient,satisfactory and safe.This model is suitable for investigation of pathophysiological mechanism associated with OLV.
【Fund】: 国家自然科学基金项目(编号:30571787)
【CateGory Index】: R-332
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