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《Acta Laboratorium Animalis Scientia Sinica》 2010-03
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Analysis of the BV Antibody Detected in Chinese Laboratory Monkeys between 2003 and 2008 and the Regularity of Its Variation

WANG Ji,WEI li,GONG Wei,YUE Bing-fei,HE Zheng-ming(National Institute for the Control of Pharmaceutical and Biological Products,National Center for Microbiological and Cenetic Monitoring of Laboratory Animals,Beijing 100050,China)  
Objective To determine the monkey B virus(BV) infection condition and variation of the BV antibody levels in Chinese laboratory monkeys,and to provide the basis for the quality control and the standardization of laboratory monkeys in China.Methods The BV antibodies in the serum of 2 breeds of monkeys from 11 units in our country were assayed according to GB ELISA,and a statistical analysis of the detection results was carried out.Results 4612 serum samples of monkeys were tested for BV antibody from 2003 to 2008,in which 1843 were positive,with a positive rate of 39.96%.During the 6 years,the positive rate among monkey groups was between 30% – 50%.The BV infection rates of monkeys at 4 different ages were as following: 26.28% in cub(≤2years old),31.53% in juvenile(2.1 ~ 4.0 years old),53.74% in adult(4.1-6.5 years old) and 87.27% in senile(≥6.5 years old) monkeys.There were significant differences in the infection rates among the 4 groups(P 0.01).The BV infection rate of female monkeys was 35.91%,slightly higher than that of the males(34.93%),with a non-significant difference between them(P 0.05).Conclusions The infection rate of BV is different in monkeys of different ages,increasing with the age.
【CateGory Index】: R446.6
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