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《Acta Laboratorium Animalis Scientia Sinica》 2011-05
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Effects of salvianolic acid B on cardiac hemodynamics in isolated working rat heart

GAO Feng1,SUN Gui-bo1,NIE Yuan-yuan1,REN Xiao-yu1,SUN Jing1,QIN Meng1, TANG Jing-shu1,SUN Xiao-bo1(1.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China;2.Eastern Liaoning College,Liaoning 118001; 3.Peking University Health Science Center,Beijing 100183)  
Objective To explore the effects of salvianolic acid B on hemodynamics in normal isolated working rat hearts.Methods The effects of salvianolic acid B on myocardiac contractility were observed by the Langendroff model,perfused SD rat heart.The hemodynamic parameters including left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),intraventricular pressure maximum upstroke velocity(+dp/dtmax),maximum decrease in the velocity of intraventricular pressure(-dp/dtmax) and heart rate(HR) on the isolated normal rat hearts were observed.Results Salvianolic acid B slowed HR and reduced LVSP,and ±dp/dtmax in a dose-dependent manner.Salvianolic acid B had no remarkable effect on LVEDP.Conclusions The salvianolic acid B of Salvia miltiorrhiza has increasing effects on the myodynamia in normal isolated working rat hearts in a dose-dependent manner.
【Fund】: 国家科技支撑计划项目(2008BAI51BO2);; 国家重大新药创制科技专项(2009ZX09301-0032009ZX09502~015);; 国家科技部项目(2008EG150298)
【CateGory Index】: R285.5
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