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《Acta Laboratorium Animalis Scientia Sinica》 2013-01
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Protective effects of aqueous extract of Cortex dictamni on myocardial ischemia reperfusion injury in rats

XU Ming-liang 1,WANG Li-li2,LI Lin2,LI Zhi-qiang3,Qin Meng2,LI Jin-ming1,XU Yang2(1.Harbin Commerce University,Harbin 150080,China;2.Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193;3.Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222002)  
Objective To investigate the protective effects of Cortex Dictamni(CD)aqueous extract on the rat models of myocardial ischemia reperfusion.Methods Wistar rats were randomly divided into sham group,ischemia reperfusion model group,positive drug group(Di Ao Xin Xue Kang) and CD low,moderate and high dose groups(CD aqueous extract 0.16,0.32,and 0.64 g/kg)(n=6).The myocardial ischemia reperfusion injury model was established through occluding the left anterior descending branch of coronary artery for 60 min and removing the ligation later to reperfuse for 30 min in vivo.Different doses of CD aqueous extract were intragastrically administered once per day for 2 weeks.The ECG changes were recorded and myocardial infarct size,MDA contents CK and SOD activity were measured.The histological changes were analyzed.Results CD significantly reduced the infarct size in a dose-dependent manner,decreased MDA content,and increased SOD activity.Histological analysis also indicated that CD could protect myocardial cells from ischemia reperfusion injury.Conclusion CD aqueous extract exerts protective effect on myocardial ischemia reperfusion injury in rats.The possible mechanism may be via the inhibition of peroxidation by increasing the antioxidant enzyme activities.
【Fund】: “重大新药创制”科技重大专项“十一五”及“十二五”计划课题(编号:2011ZX09401-014 2012ZX09103201-012)
【CateGory Index】: R285.5
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