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Protective Effect of Saponins of Panax Notoginseng on Cerebral Ischemia

Ma Liyan,et al (Institute of Medicinal Plant Development ,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing)  
The effects of saponins of Panax Notoginseng (PNS) in complete brain ischemia and in rat middle cerebral artery occlussion (MCAO) model were studied in present paper,PNS (50,100 mg.kg -1 ×3d ,ip) significantly prolonged the duration of gasping of mice subjected to complete brain ischemia induced by decapitation or intravenous injection of MgCl 2. Treatment with PNS 200 mg.kg -1 ip was performed 30 min before or 15 min after MCAO. The infarcted area and the neurological deficit 24h following MCAO were reduced by PNS compared with the saline treated group.The neuronal injury determined by histopathological examination Was also attenuated.We could come to the Conclusion that PNS protect brain from ischemic damage.
【CateGory Index】: R285.5
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