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The Effect of Progesterone on the Development of the Uterine Leiomyoma

Sun Lan *,Wu Jie,Xu Fudan,et al\ *Department of pathology,Tong Ren Hospital,Shanghai 200050  
Objective\ To investigate the effect of progesterone on the development of the uterine leiomyoma.Methods\ 132 specimens of uterine leiomyoma were studied by using histological methods.The number of nucleus division in 100HPF and its relation to proliferative phase,secretory phase,and the age of the patients were observed.Results\ We discovered that the number of nucleus division in the late secretory phase with the highest level of progesterone(5 9/100HPF)was significantly higher than that in the proliferative phase(1 8/100HPF, P 0 01).The number of nucleus division in the secretory phase of the youth group is significantly higher than that in the aged group( P 0 01).Conclusions\ These findings suggested that progesterone is one of the promoting factor for the uterine leiomyoma development.
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