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《CHINESE JOURNAL OF APPLIED PHYSIOLOGY》 1997-03
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EFFECTS OF LITHIUM ON THE PROLIFERATION OF MURINE HIGH PROLIFERATIVE POTENTIAL COLONY FORMING CELLS AND GRANULOCYTE MACROPHAGE COLONY FORMING UNIT IN VITRO

Xia Tian, Jiang Dezhao (Department of Blood Physiology, Hunan Medical University, Changsha,410078)  
The effects of LiCl on the proliferation of high proliferative potential colony forming cells (HPP CFC) and granulocyte macrophage colony forming unit (CFU GM) from bone marrow of BALB/c mice were observed. The colonies of HPP CFC were supported by IL 1,IL 6, WEHI 3 conditioned medium (WEHI 3 CM, which contained IL 3) and L929 conditioned medium (L929 CM,which contained M CSF); the colonies of CFU GM were supported by WEHI 3 CM. It was shown that LiCl at concentrations ranging from 0 4mmol/L to 2mmol/L significantly inhibited the proliferation of HPP CFC ( P 0 01), but concentrations ranging from 0 4 mmol/L to 1mmol/L significantly increased the production of CFU GM ( P 0 05),both effects displayed in dose dependent manners. The different effects of LiCl on the proliferation of HPP CFC and CFU GM suggest that LiCl may induce HPP CFC differentiation into more mature cells.
【Fund】: 湖南省科委科研基金
【CateGory Index】: R-332
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG Cheng-Long LI Wei-Min WANG Qi-Ru (Experimental Hemophysiology Laboratory, Hunan Medical University Changsha 410078);BIOLOGICAL CHARACTERISTICS OF L929 CELL LINE[J];实验血液学杂志;1995-04
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Huang Xiaoqin,Zhu Bide∥Sichuan Continuing Education College of Medical Science,Cheng du 610041;The Experimental Study on L cell Regulate Hematopoiete Effected by IL 1[J];四川省卫生管理干部学院学报;1999-03
2 Huang Xiaogin Zhu BideDepartment of Anatomy, Sichuan Continuing EducationCollege of Medical Sciences, Chengdu 610041;An Experimental Study on L-cell HRF Induced by TSPG[J];四川解剖学杂志;1998-04
3 Xia Tian Jiang Dezhao(Research Laboratory of Blood Physiology, Hunan Medical University, Changsha 410078);Culture of murine HPP-CFC in vitro using conditioned mediumsubstitute for recombinant growth factors[J];湖南医科大学学报;1998-02
4 Xia Tian, Jiang Dezhao (Department of Blood Physiology, Hunan Medical University, Changsha,410078);EFFECTS OF LITHIUM ON THE PROLIFERATION OF MURINE HIGH PROLIFERATIVE POTENTIAL COLONY FORMING CELLS AND GRANULOCYTE MACROPHAGE COLONY FORMING UNIT IN VITRO[J];中国应用生理学杂志;1997-03
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