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《CHINESE JOURNAL OF APPLIED PHYSIOLOGY》 1997-03
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EFFECTS OF LITHIUM ON THE PROLIFERATION OF MURINE HIGH PROLIFERATIVE POTENTIAL COLONY FORMING CELLS AND GRANULOCYTE MACROPHAGE COLONY FORMING UNIT IN VITRO

Xia Tian, Jiang Dezhao (Department of Blood Physiology, Hunan Medical University, Changsha,410078)  
The effects of LiCl on the proliferation of high proliferative potential colony forming cells (HPP CFC) and granulocyte macrophage colony forming unit (CFU GM) from bone marrow of BALB/c mice were observed. The colonies of HPP CFC were supported by IL 1,IL 6, WEHI 3 conditioned medium (WEHI 3 CM, which contained IL 3) and L929 conditioned medium (L929 CM,which contained M CSF); the colonies of CFU GM were supported by WEHI 3 CM. It was shown that LiCl at concentrations ranging from 0 4mmol/L to 2mmol/L significantly inhibited the proliferation of HPP CFC ( P 0 01), but concentrations ranging from 0 4 mmol/L to 1mmol/L significantly increased the production of CFU GM ( P 0 05),both effects displayed in dose dependent manners. The different effects of LiCl on the proliferation of HPP CFC and CFU GM suggest that LiCl may induce HPP CFC differentiation into more mature cells.
【Fund】: 湖南省科委科研基金
【CateGory Index】: R-332
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Jiang Dezhao Xu Youheng Li Meifan Yuan Weidao Wang Qiru Research Laboratory of Blood Physiology, Hunan Medical College;LITHIUM PROTECTS MOUSE BONE MARROW CELLS FROM THE MYELOSUPPRESSIVE EFFECT OF HARRINGTONINE[J];;1985-04
2 WANG Cheng-Long LI Wei-Min WANG Qi-Ru (Experimental Hemophysiology Laboratory, Hunan Medical University Changsha 410078);BIOLOGICAL CHARACTERISTICS OF L929 CELL LINE[J];Journal of Experimental Hematology;1995-04
【Co-citations】
Chinese Journal Full-text Database 4 Hits
1 Jiang Dezhao Li Meifan Zhou YanjiaoResearch Laboratory of Blood Physiology;PROTECTION OF MURINE BONE MARROW GRANULOPOIESIS FROM IRRADIATION GFFECT BY LITHIUM[J];;1988-02
2 Xia Tian Jiang Dezhao(Research Laboratory of Blood Physiology, Hunan Medical University, Changsha 410078);Culture of murine HPP-CFC in vitro using conditioned mediumsubstitute for recombinant growth factors[J];BULLETIN OF HUNAN MEDICAL UNIVERSITY;1998-02
3 Huang Xiaogin Zhu BideDepartment of Anatomy, Sichuan Continuing EducationCollege of Medical Sciences, Chengdu 610041;An Experimental Study on L-cell HRF Induced by TSPG[J];Sichuan Journal of Auatomy;1998-04
4 Huang Xiaoqin,Zhu Bide∥Sichuan Continuing Education College of Medical Science,Cheng du 610041;The Experimental Study on L cell Regulate Hematopoiete Effected by IL 1[J];JOURNAL OF SICHUAN CONTINUING EDUCATION COLLEGE OF MEDICAL SCIENCES;1999-03
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Wang Qiru Sun Xiuhong Huang Qichen Li Meifen Department of Physiology,Hunan Medical College;AN IN VIVO DIFFUSION CHAMBER TECHNIQUE FOR QUANTITATION OF HAEMOPOIETIC STEM CELL Ⅰ.The Diffusion Chamber Culture Technique for Granulocytic Committed Stem Cells[J];;1980-03
2 Fan Ijun~* and Han Rui(Institute of Materia Medica, The Chinese Academy of Medical Sciences, Beijing);THE EFFECT OF HARRINGTONINE ON THE CELL CYCLE OF L-1210 CELLS AND THE BONE MARROW STEM CELLS IN MICE[J];Acta Pharmaceutica Sinica;1979-08
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